Enormous progress has been made in the last half-century in the management of diseases closely integrated with excess body weight, such as hypertension, adult-onset diabetes and elevated cholesterol. However, the treatment of obesity itself has proven la
costeffectiveness platform.We applied the technology into the Balb/c mouse IgG repertoire study.We systematically analyzed their germlines,V,D,J genes and identified some interesting results.This study provides some insights for antibody discovery from B cells and possible other antibody discovery ...
The next generation of antibody–drug conjugates comes of age. Discov. Med. 10, 329–339 (2010). PubMed Google Scholar Senter, P. D. & Sievers, E. L. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. ...
Nevertheless, the efficacy and safety profile of antibody drug conjugates is not yet optimal.Area CoveredThis article primarily summarizes the challenges that need to be addressed during the development of various strategies for the discovery of antibody-drug conjugates in oncology. The authors further ...
Antibody Validation and Challenges Complementary RNA & Protein Analysis Reference Standards RNAscope ISH validates antibodies and is a powerful alternative Failed IHC image customer IHC is a widespread technology and remains the gold standard for a broad range of application going from discovery to diagno...
antibody-drug conjugatesbiologicsdrug developmentimmunotoxinsmAbsoligonucleotidesrecombinant proteinssafety evaluationsmall moleculesImportance of the field: The prediction of human toxicity by employing animal models for nonclinical safety evaluation of pharmaceuticals poses numerous challenges. Each type, biologics,...
Surrogate approaches in development of monoclonal antibodies When cross-reactivity of a lead antibody across species is limited, antibody development programs require the generation of surrogate molecules or surrogat... GG Bornstein,SL Klakamp,L Andrews,... - 《Drug Discovery Today》 被引量: 22发表...
The most optimal approach is to develop a single PK assay, using a single analytical standard, for quantitative measurement of the biosimilar and reference... Alex,Colbert,Amber,... - 《Mabs》 被引量: 17发表: 2014年 Demonstrating biosimilar and originator antidrug antibody binding comparability ...
Potential approaches to kill tumour-initiating cells include inhibiting the survival mechanisms of these cells, blocking essential self-renewal signalling, or targeting tumour-initiating cell surface markers through antibody-based cytotoxic approaches. Another strategy is to induce tumour cell differentiation,...
The discovery of oestrogen receptor β (ERβ/ESR2) was a landmark discovery. Its reported expression and homology with breast cancer pharmacological target ERα (ESR1) raised hopes for improved endocrine therapies. After 20 years of intense research, thi