Antibacterial Discovery Performance Unit, Infectious Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline, Collegeville, PennsylvaniaJohn Wiley & Sons, LtdAnnals of the New York Academy of SciencesGwynn MN, Portnoy A, Rittenhouse SF, Payne DJ. 2010. Challenges of antibacterial discovery ...
摘要原文 SUMMARY The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output...
Antibacterial pipelines Drug discovery Expert panel Funding applications Introduction Bacterial resistance is a global problem that affects not only patients but all parts of society, animals, and the environment. High resistance rates in some countries contrast rather thin clinical pipelines [1] which ar...
Singh SB. Confronting the challenges of discovery of novel antibacterial agents. Bioorganic & medicinal chemistry letters. 2014;24(16):3683-9.Singh SB (2014) Confronting the challenges of discovery of novel antibacterial agents. Bioorg Med Chem Lett 24: 3683-3689....
Drugs for bad bugs: confronting the challenges of antibacterial discovery Nat Rev Drug Discov, 6 (2007), pp. 29-40 CrossrefView in ScopusGoogle Scholar 53 S.I. Miller Antibiotic resistance and regulation of the gram-negative bacterial outer membrane barrier by host innate immune molecules mBio,...
L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Rev. Drug Discovery 2007, 6 (1), 29-40.Geoffrey D. Coxon,Christopher B. Cooper,Stephen H. Gillespie.Strategies and Challenges Involved in the Discovery of New Chemical Entities During Early-Stage Tuberculosis ...
Kelly et al.'s27 analysis of European public funding of antibacterial research found that 86% of national-level public funding in antibiotic therapeutics was for basic research. The beneficiaries of this funding tend to be academic research groups, instead of the private SMEs, who often need ...
et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect. Dis. 18, 318–327 (2018). Article PubMed Google Scholar World Health Organization. Antibacterial Agents in Clinical Development: an Analysis of ...
it has been shown that CDs possess many antibacterial properties, with their antibacterial mechanisms involving oxidative stress, physical damage, and suppression in the metabolic process of bacteria [30]. Food packaging can benefit from the additional usage of carbon dots (CDs), which are made of...
Tacconelli, E. et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.Lancet Infect. Dis.18, 318–327 (2018). ArticlePubMedGoogle Scholar World Health Organization.Antibacterial Agents in Clinical Development: an Analysi...