摘要原文 SUMMARY The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output...
Genomic approaches have not yielded satisfactory results, in part due to nascent knowledge about unprecedented molecular targets, the challenge of achieving antibacterial activity by lead optimization of enzyme inhibitors, and the limitations of compound screening libraries for antibacterial discovery. Enhanced...
Singh SB. Confronting the challenges of discovery of novel antibacterial agents. Bioorganic & medicinal chemistry letters. 2014;24(16):3683-9.Singh SB. 2014. Confronting the challenges of discovery of novel antibac- terial agents. Bioorg Med Chem Lett 24:3683-3689. http://dx.doi.org/10 ....
L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Rev. Drug Discovery 2007, 6 (1), 29-40.Coxon GD, Cooper CB, Gillespie SH, McHugh TD. Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery...
Drugs for bad bugs: confronting the challenges of antibacterial discovery Nat Rev Drug Discov, 6 (2007), pp. 29-40 CrossrefView in ScopusGoogle Scholar 53 S.I. Miller Antibiotic resistance and regulation of the gram-negative bacterial outer membrane barrier by host innate immune molecules mBio,...
Design and Discovery of New Antibacterial Agents: Advances, Perspectives, Challenges. J Jampilek - Curr Med Chem 被引量: 0发表: 2019年 Resistance to antifungal agents in the critical care setting: Problems and perspectives As is the case with antibacterial agents, the increasing use of antifungal...
REVIEW Antibacterial resistance worldwide: causes, challenges and responses Stuart B Levy & Bonnie Marshall The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are ...
Identification of novel antibacterial peptides by chemoinformatics and machine learning. The rise of antibiotic resistant pathogens is one of the most pressing global health issues. Discovery of new classes of antibiotics has not kept pace; new... CD Fjell,H Jenssen,H Kai,... - 《Journal of ...
Kelly et al.'s27 analysis of European public funding of antibacterial research found that 86% of national-level public funding in antibiotic therapeutics was for basic research. The beneficiaries of this funding tend to be academic research groups, instead of the private SMEs, who often need ...
et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect. Dis. 18, 318–327 (2018). Article PubMed Google Scholar World Health Organization. Antibacterial Agents in Clinical Development: an Analysis of ...