Advances in Antibody Design and Antigenic Peptide Targeting 2.0doi:10.3390/ijms24098033PEPTIDESDESIGNTrier, Nicole HartwigHouen, GunnarInternational Journal of Molecular Sciences
Bispecific and multispecific antibodies in oncology: opportunities and challenges Article 31 May 2024 Emerging new therapeutic antibody derivatives for cancer treatment Article Open access 07 February 2022 References Goulet, D. R. & Atkins, W. M. Considerations for the design of antibody-based ...
The advent of biologic therapies, particularly antibody therapeutics, has revolutionized the pharmacological treatment of many rheumatic diseases. Antibody discovery began with the immunization of mice for the production of rodent immunoglobulins, but advances in protein and genetic engineering have now made...
Recent advances in computational methods are ushering in a new era of antibody design, driven in part by accurate structure prediction. Previously, structure-based antibody design has been limited to a relatively small number of cases where accurate structures or models of both the target antigen ...
Overall, the linkage between the antibody and NPs is a critical subject and requires precise design and development. The attachment of antibody nanoconjugates (Ab-NCs) on the antigen surface shouldn't affect the function of the antibody-antigen binding. Also, the stability of the antibody nano...
Design, construction, and characterization of a large synthetic human antibody phage display library Advances in proteomic research allow the identification of several hundred protein components in complex biological specimens. Structural information is ty... Michela,Silacci,Simon,... - 《Proteomics》 被...
Recent advances in the design and administration of immunotoxins are overcoming historical challenges in the field, leading to renewed interest in these therapeutics.关键词: Antibody conjugate Antidrug antibody Recombinant immunotoxin Vascular leak syndrome ...
An overview of monoclonal antibody therapy of cancer. Monoclonal antibody-based therapeutics are beginning to realize the promise that was predicted with the advent of the core technology more than 20 years ag... LM Weiner - 《Seminars in Oncology》 被引量: 469发表: 1999年 Characterisation of ...
Keywords Phage display Antibody discovery Antigen presentation Selection strategy Library design Sorry, something went wrong. Please try again and make sure cookies are enabledReferences 1. G.P. Smith Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface ...
gene therapy. However, AAVs do have flaws and this has prompted research aimed at improving design of novel and artificially synthesised AAVs. Main goals are to improve liver transduction efficiencies and avoiding immune clearance. Application of AAVs to model HBV replication in vivo is also ...