The White House also hopes to fund the discovery of new antibiotics to kill drug-resistant bacteria and the development of diagnostics to rapidly detect them. The plan is called 'the National Action Plan for Combating Antibiotic-Resistant Bacteria' and is focused on C. difficile, carbapenem-...
Studies have also shown that MPER-directed Abs rely more on lipid interactions, which are not included in the scaffolded epitope105, highlighting another key consideration—epitope context. Such interactions with the lipid bilayer or with glycans may be important for the antibody binding and may ...
After a 30-min blocking step with the universal blocking serum (Dako Diagnostics, Carpinteria, CA), the sections were incubated with anti-Sp1 antibody at 4 °C overnight and washed 3 times with PBS at room temperature. Then a secondary, HRP-conjugated antibody was added for 30 min ...
GSK has announced that its investigational antibodydrug conjugate ADC GSK GSK has been granted Breakthrough Therapy Designation by the US Food and Drug Administration FDA Astellas Pharma Announces Approval of VYLOYTM for Advanced Gastric Cancer
CCS:The name Fab was originally meant to stand for “female antibody,” but with that pivot it became “female autoimmune biologic,” which is more expansive. GS:With antibodies, there are so many possibilities: traditional drug discovery methods like phage display or the use of transgenic mice...
Reports on developments related to the pharmaceutical industry in the U.S. as of February 2003. Investigational New Drug application filed by Eos Biotechnology Inc. for its therapeutic antibody, Eos200-4; Phase II clinical trial initiated by Millennium Ph...
Antibody drug conjugates ADCs are innovative modalities to deliver chemotherapeutics to specifically targeted populations of cancer cells CLINICAL TRIALS New MHLW Guidance Aims to Facilitate Inclusion of Japanese Participants in Global Clinical Trials
(TAMs), and cancer-associated fibroblasts than females. Furthermore, compared with anti-PD-L1 antibody alone, the combination of E2 with anti-PD-L1 antibody significantly inhibited MC38 tumor growth and decreased PD-L1 expression and M2/M1 TAM ratio. This observation suggests that E2 may ...
(such as AI-enabled large-molecule and antibody design). Current AI-driven drug discovery companies are already developing their own, significantly more cost-efficient drug discovery pipelines, so it would be beneficial for established players to identify how they, too, can fully inte...
The primary antibody solution was incubated for 1.5 h at room temperature using the following antibodies: mouse monoclonal anti-phospho-S139-H2AX antibody (1:500, clone JBW301, Millipore, Darmstadt, Germany) and rabbit polyclonal 53BP1 antibody (1:500, Novus Biologicals, Wiesbaden, Germany). ...