2021年3月,美国德克萨斯大学奥斯汀分校联合碧迪医疗生命科学在线发文(High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8+T cells),该研究借助BD Rhapsody™单细胞多组学平台,对抗原特异性CD8+T细胞实现了 “三高” 的单细胞分析,让我们来先睹为快吧! “三高” 特点描述 ■ 高通量...
Schmidt, J., et al. Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors. Nat Commun 14, 3188 (2023). Schumacher, T. N., Scheper, W. & Kvistborg, P. Cancer neoantigens. Annu. Rev. Immunol. 37, 173–200 (2019). Oliveira, G. et...
Cluster T6 was characterized as naive CD8+ T cells with the high expression of CCR7, LEF1, and CD27. 更多的时候其实是打分,并不能完全是看某个基因或者某些基因在某个单细胞亚群里面的排他性的特异性高表达,比如 resident, cytotoxic, exhausted, and costimulatory score for CD8 T cells. 5 resident ...
Cluster T6 was characterized as naive CD8+ T cells with the high expression of CCR7, LEF1, and CD27. 更多的时候其实是打分,并不能完全是看某个基因或者某些基因在某个单细胞亚群里面的排他性的特异性高表达,比如 resident, cytotoxic, exhausted, and costimulatory score for CD8 T cells. 5 resident ...
, cytokine production, and T cell activation. Tranomic profiling and biochemical interrogation revealed arole for DHX37 in modulating NF-κB. These data demonstrate high-throughput invivo genetic screens for immunotherapy target discovery and establishes DHX37 as a functional regulator of CD8 T cells...
22. Fehlings M, et al. Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells. Nat Commun. 2017; 8 23. Chevrier S, et al. An ...
Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4–dependent (GPX4-dependent)ferroptos...
Cluster T6 was characterized as naive CD8+ T cells with the high expression of CCR7, LEF1, and CD27. 更多的时候其实是打分,并不能完全是看某个基因或者某些基因在某个单细胞亚群里面的排他性的特异性高表达,比如 resident, cytotoxic, exhausted, and costimulatory score for CD8 T cells. ...
Although the number of virus-specific cells elicited is unquestionably important, recent studies have identified an additional parameter, functional avidity, as critical in determining the efficiency of viral clearance. T-cell avidity is a measure of the sensitivity of a cell to peptide antigen. High...
expressed by HBV-specific CD8 T cells with high levels of Bim and helps to drive this5个回答 表示特定于乙型肝炎病毒的 CD8 T 细胞水平较高的毕姆和有助于推动该 2013-05-23 12:21:38 回答:匿名2013-05-23 12:23:18 回答:匿名2013-05-23 12:24:58 回答:匿名表示特定于乙型肝炎病毒的 CD8 T ...