Although the number of virus-specific cells elicited is unquestionably important, recent studies have identified an additional parameter, functional avidity, as critical in determining the efficiency of viral clearance. T-cell avidity is a measure of the sensitivity of a cell to peptide antigen. High...
Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4–dependent (GPX4-dependent) ferropt...
摘要 CD8+ T cells control tumors but inevitably become dysfunctional in the tumor microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction to promote cancer regression. NaCl supplementation during CD8+ T cell culture induced effector differentiation, IFN-γ prod...
Cluster T6 was characterized as naive CD8+ T cells with the high expression of CCR7, LEF1, and CD27. 更多的时候其实是打分,并不能完全是看某个基因或者某些基因在某个单细胞亚群里面的排他性的特异性高表达,比如 resident, cytotoxic, exhausted, and costimulatory score for CD8 T cells. 5 resident ...
CD8+T细胞,又称为细胞毒性T细胞,是机体适应性免疫应答的重要组成部分,在结核分枝杆菌感染情况下,受到抗原提呈细胞活化的CD8+T细胞主要通过释放IFN-γ、IL-6、IL-1和TNF-α等细胞因子激活天然免疫细胞的杀菌能力,或者通过细胞毒机制直接杀...
细胞毒性T细胞(CD8+T细胞)概述 CTL是什么细胞? 细胞毒性T淋巴细胞(CTL细胞)通常称为CD8+T细胞,是适应性免疫系统的关键组成部分,在免疫系统抵御病原体(如病毒、细菌和肿瘤)中发挥重要作用[1]。 辅助性CD4+T细胞(如Th1、Th2、Th9、Th17、Th22、Tfh和Treg)是在胸腺中生成...
We describe a high-dimensional, tetramer-associated T cell antigen receptor (TCR) sequencing (TetTCR-SeqHD) method to simultaneously profile cognate antigen specificities, TCR sequences, targeted gene expression and surface-protein expression from tens of thousands of single cells. Using human ...
细胞毒性T细胞(CD8+T细胞)概述 CTL是什么细胞? 细胞毒性T淋巴细胞(CTL细胞)通常称为CD8+T细胞,是适应性免疫系统的关键组成部分,在免疫系统抵御病原体(如病毒、细菌和肿瘤)中发挥重要作用[1]。 辅助性CD4+T细胞(如Th1、Th2、Th9、Th17、Th22、Tfh和Treg)是在胸腺中生成并表...
Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 Jun;606(7916):945-952. doi: 10.1038/s41586-022...
急性感染中,CD8+初始T细胞在接受抗原刺激之后,可分化为 CD8+效应T细胞 (effector CD8+ T cells, TEFF) .如果抗原被清除,一部分的TEFF会持续存在,形成长寿的可以自我更新的记忆T细胞 (memory CD8+ T cells, TMEM ) ,以对再次感染产生快速的免疫反应.相反,在慢性感染或者肿瘤中,抗原持续存在,初始T细胞的分化将会...