CD8 T细胞(Cytotoxic T lymphocytes, CTLs)在这一过程中扮演了重要角色,其中一种特殊亚群——组织驻留记忆CD8 T细胞(Tissue-resident memory CD8 T cells,简称TRM细胞),尤为引人注目。 TRM细胞能够长期驻留在非淋巴组织,成为“常驻型”...
论文ID 题目:Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis 译名:类风湿关节炎患者细胞毒性CD8+T细胞靶向瓜氨酸抗原的研究 期刊:Nature Communications IF:17.394 发表时间:2023.1.19 通讯作者单位:斯坦福大...
8.Groh, J., Knöpper, K., Arampatzi, P. et al. Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Nat Aging 1, 357–367 (2021). https://doi.org/10.1038/s43587-021-00049-z 9.Gate, D., Saligrama, N., ...
CD8+细胞毒性T细胞（cytotoxic T cell, CTL），在清除胞内菌、病毒等外界病原和肿瘤细胞过程中发挥着重要作用。T细胞受体（T cell receptor, TCR）信号传导是决定静息期CD8+ T细胞活化成CD8+ CTL的关键。此外，T细胞迁移到达病灶部位也是T细胞成功杀伤病原微生物或肿瘤的关键因素。比如，回输CAR-T细胞的免疫疗法在白...
CD8+ Cytotoxic T-Cellsdoi:10.1007/978-3-540-47648-1_918Synonym TC, CTL, T-Killer cell or killer T cell; belong to a sub-group of T-cells capable of inducing the death of cancer cells. Most cytotoxic T cells express T-cell receptors (TcRs) that can...Springer Berlin Heidelberg...
2. Leong, Y.A., et al., CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol, 2016.3. Im, S.J., et al., Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature, 2016. 537(7620): p. 417-421.4. He, R., ...
Clonally expanded CD38hi cytotoxic CD8T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis Science Immunology; IF: 24.800; DOI: 10.1126/sciimmunol.add1591 内容概要:通过scRNA-seq和抗原受体库分析,比较由免疫检查点抑制剂(Immune checkpoint inhibitor,ICI)治疗引起的炎症性关节炎(...
Cytotoxic T cells Latest Research and Reviews Two-stage CD8+CAR T-cell differentiation in patients with large B-cell lymphoma Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease group with CAR T cells offering therapeutic success in otherwise hard-to-treat cases. Here, authors study...
et al. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell 184, 4512–4530.e22 (2021). Article PubMed PubMed Central Google Scholar Zheng, L. et al. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science 374, abe6474...
近日,哈佛医学院Allegra A. Petti和Gavin P. Dunn、布列根和妇女医院Tanner Johanns联合在Cancer discovery期刊上发表题为Glioblastoma-infiltrating CD8+T cells are predominantly a clonally expanded GZMK+effector population的研究论文,使用多组学方法对脑胶质瘤患者的T细胞进行测序,发现典型的T细胞耗竭标志在高级别胶质...