In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3 and CD8 T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found ...
However, glucocorticosteroids fail to adequately suppress granzyme B production by CD8 T cells. We previously showed that low-dose azithromycin reduced airways inflammation in COPD subjects and we hypothesized that it would also reduce granzyme B production by CD8 T cells. Methods We administered 250...
CD8 T cells were separated, then incubated with activation for 48 hr, and NF-kappaB and Bcl-2 analysis was carried out using Western immunoblotting. The CD4:CD8 ratio wasincreased in SSc compared to controls (2.6 +/- 1.13 vs.1.87 +/- 0.76; P = 0.018). The spontaneous apoptosis rate ...
Functional profiling of CD8 T cells in low-dose IL-2 treated patients revealed an increased in the frequencies of CEF viral peptide specific TNF-a and Grazmy-B CD8 T cells. Moreover, low-dose IL-2 treated patients showed stronger antigen-specific response demonstrated by an increased ...
CD8 + T cells can express NK-associated receptors (NKRs) that may regulate their cytolytic function. We have characterized the expression of several NKRs on peripheral blood CD8 + T cells from melanoma patients and compared them to age-matched healthy donors. The analysis performed includes HLA...
We monitored expression of PD-1, a marker of T-cell exhaustion and viral persistence, on CD8 T cells in patients who resolved EBV infection as determined by undetectable EBV DNA (REI) and CHL patients. PD-1 expression on CD8 T cells was increased in the first year post-transplant ...
Increased frequency of CD69+CD8+T cells in the circulation of patients with PsA We have characterized the expression of the activation marker/tissue retention molecule CD69 and chemokine receptors in the circulating compartment of CD8+and CD4+T cells from patients with PsA, patients with cutaneous...
Importantly, we identified an exhausted natural killer group protein 2A (NKG2A)+CD8+T-cell subset that was associated with the severity of adenomyosis and found that the number of these cells was significantly increased in the eutopic endometrium and ectopic lesions. In addition, the increases in...
MC numbers and interactions with CD8+ T-cells are increased in the humanized-mouse model of AA. B Marta 被引量: 0发表: 2014年 Dynamics of Human Respiratory Virus-Specific CD8+ T Cell Responses in Blood and Airways during Episodes of Common Cold We determined the dynamics of CD8+ T cells...
F5 TCR transgenic mice challenged in vivo with peptide generate long-lived primed CD8 T cells that hyper-proliferate in response to peptide in vitro. These primed CD8 T cells can be subdivided into three distinct populations on the basis of CD44 cell surface expression. In this report, we show...