近日,加州大学旧金山分校的Matthew H. Spitzer团队在Cell上发表题为Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes的文章中,研究人员综合运用单细胞技术:single-cell analyses by mass cytometry (CyTOF)、single-cell RNA sequencing and...
在免疫学和医学领域，CD8分子常作为T细胞表面的抗原标记物，被用于T细胞流式检测。CD8检测有助于某些感染性疾病、免疫性疾病的诊断与治疗。参考文献：● Aichele, Peter et al. Immunopathology caused by impaired CD8+ T-cell responses. European journal of immunology, 2022 .● Zhang, Nu, and Michael J Be...
近日，来自德国慕尼黑工业大学的Jan P. Bottcher团队在Cancer Cell杂志上发表了一篇题为 A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity 的文章，他们使用基于成像的深度学习方法来确定肿瘤内cDC1-CD8+T细胞群是保护性抗癌免疫的一个独特特征...
Spitzer团队在Cell上发表题为Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes的文章中,研究人员综合运用单细胞技术:single-cell analyses by mass cytometry (CyTOF)、single-cell RNA sequencing and TCR sequencing (sc-RNA+TCR-seq)...
近日,约翰·霍普金斯大学医学院的Michael Lim团队在Immunity杂志上发表了文章The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function,他们证明METRN是肿瘤微环境(TME)中免疫细胞分泌的一...
[1]Jackson C M, Pant A, Dinalankara W, et al. The cytokine Meteorin-like inhibits anti-tumor CD8+ Tcell responses by disrupting mitochondrial function[J]. Immunity, 2024. [2]Rao R R, Long J Z, White J P, et al. Meteorin-like is a hormone that regulates immune-adipose interactions...
Spitzer教授在《Cell》发表了题为“Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes”的文章。传统的固有免疫刺激CD8+ T细胞是介导免疫检测点抑制治疗的中枢效应细胞。小鼠研究发现,免疫检测点抑制需要次级淋巴器官中的CD8+ T细胞响应。
近日,约翰·霍普金斯大学医学院的Michael Lim团队在Immunity杂志上发表了文章The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function,他们证明METRN是肿瘤微环境(TME)中免疫细胞分泌的一种代谢活性细胞因子,可促进TME中TIL功能减退。从机制上讲,METRNL增加了PPARδ活性...
近日,约翰·霍普金斯大学医学院的Michael Lim团队在Immunity杂志上发表了文章The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function,他们证明METRN是肿瘤微环境(TME)中免疫细胞分泌的一种代谢活性细胞因子,可促进TME中TIL功能减退。从机制上讲,METRNL增加了PPARδ活性...
Samples from four patients with no response to anti-PD-1 also demonstrated neoantigen-specific T cell responses in the blood and tumour to a restricted number of mutations with lower TCR polyclonality and were not recurrently detected in sequential samples. Reconstitution of the neoTCRs in donor ...