Moreover, we will discuss how stem-cell like and resident memory CD8(+) T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8(+) T cell subsets together orchestrate durable immunity to cancer....
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed memory CD8+ T-cell responses acr
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...
In-depth transcriptional profiling of CD8+ TILs suggests that distinct subsets of TRM cells with heterogeneous phenotypic or functional properties can coexist in the same tumor 75., 80., 86., Mechanisms of TRM Cell Cancer Immunosurveillance In theory, CD8+ T cells could enact tumor suppression ...
Our data show that the suppressive and helper functions of CD8(+) T cells are differentially expressed at different phases of CDS(+) T-cell responses. Selective performance of helper functions by memory (in contrast to effector) CD8(+) T cells helps to explain the phenomenon of immune memory...
We report that the hallmarks of tumor recognition in ovarian cancer-infiltrating T cells are primarily restricted to tissue-resident memory (TRM) cells. Single-cell RNA/TCR/ATAC sequencing of 83,454 CD3+CD8+CD103+CD69+ TRM cells and immunohistochemistry of 122 high-grade serous ovarian cancers ...
Characterisation of CMV CD8+T-cell memory-inflation to immediate early HLA-C restricted targets and the potential of CMV as a vaccine vector for cancer therapy CMV CD8+T-cell memory-inflation can occupy up to 50% of the total CD8+ T cell pool. Studies using an MHC class I immunevasion-...
CXCR6-deficient tumor-specific CD8 + T cells showed reduced retention in tumor tissues, leading to diminished resident memory responses and poor control of ovarian cancer. Conclusions CXCR6, by promoting retention in tumor tissues, serves a critical role in resident memory T cell-mediated ...
CD8 + T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Here we used two-photon intravital microscopy to visualize the responses of CD8 + resident memory T cells (T RM cells) within the r... LK Beura,JS Mitchell,EA Thompson,... - 《Nature Immuno...
We have previously demonstrated that temporary depletion of CD4 T cells in mice with progressive B16 melanoma, followed by surgical tumor excision, induces protective memory CD8 T cell responses to melanoma/melanocyte antigens. We also showed that persistence of these CD8 T cells is supported, in ...