‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...
北京大学基础医学院博士生翟洢颉和博士后梁晓婷为该论文共同第一作者,北京大学国际癌症研究院研究员邓觅为该论文通讯作者。 Cite this article as:Zhai Y, Liang X, Deng M. Myeloid cells meet CD8+ T cell exhaustion in cancer: What, why and how. Chin J Cancer Res 2024;36(6):616-651. doi: 10.21...
1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 会议内容 时间:2021年10月22-23日 地点:上海(酒店后期定向通知) 规模:600-800人 主办单位:生物制品圈、抗体圈 协办单位:百英生物 学术支持:百奥泰生物 赞助单位:丹纳赫生命科学、香港奥星集团、...
J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. Rev. Immunol. 37, 457–495 (2019). CAS PubMed Google Scholar Baumeister, S. H., Freeman, G. J., Dranoff, G. & Sharpe, A. H. Coinhibitory pathways in immunotherapy for cancer. Annu. Rev. Immunol. 34, ...
Triple-negative breast cancer (TNBC)CD8Cancer immunotherapyTumor microenvironment (TME)Reverse CD8+T-cell exhaustion o boost TNBC immunotherapy.TCF1, TOX define CD8+Tex subsets for precise immunotherapy.Metabolic remodeling in hypoxic TNBC may lead future research.PD-1/L1 blockade main in TNBC, APCs...
1 Hashimoto, M. et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annual review of medicine 69, 301-318, doi:10.1146/annurev-med-012017-043208 (2018).2 McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T Cell Exhaustion During ...
2.Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006 Feb 9;439(7077):682-7. doi: 10.1038/nature04444. Epub 2005 Dec 28.3.CD8+ T Cell Exhaustion in Cancer....
1 Hashimoto, M. et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.Annual review of medicine69, 301-318, doi:10.1146/annurev-med-012017-043208 (2018). 2 McLane, L. M., Abdel-Hakeem, M....
近日，来自美国宾夕法尼亚大学的E. John Wherry带领团队在Science Immunology杂志以 In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40 发表了他们最新的研究成果，他们建立一种体外T细胞模型，能够很好的模拟慢性感染或者癌症引起的T细胞耗竭生物学功能，他们将这种...
CD8+T cell subpopulations in murine and human lung tumors. Collagen-induced T cell exhaustion occurs through the receptor LAIR1, which is upregulated following CD18 interaction with collagen, and induces T cell exhaustion through SHP-1. Reduction in tumor collagen deposition through LOXL2 ...