Figure 1. CD8 T cell exhaustion correlates with macrophage abundance in the TME Figure S1. Onset of CD8 T cell exhaustion is antigen-specific and correlates with macrophage abundance in multiple mouse cancer models 2. CD8 Tex在TME中长期驻留后表达单核/巨噬细胞相关因子 TAM丰度与CD8 T细胞耗竭之间...
1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 会议内容 时间:2021年10月22-23日 地点:上海(酒店后期定向通知) 规模:600-800人 主办单位:生物制品圈、抗体圈 协办单位:百英生物 学术支持:百奥泰生物 赞助单位:丹纳赫生命科学、香港奥星集团、...
2.Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006 Feb 9;439(7077):682-7. doi: 10.1038/nature04444. Epub 2005 Dec 28.3.CD8+ T Cell Exhaustion in Cancer....
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...
1 Hashimoto, M. et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annual review of medicine 69, 301-318, doi:10.1146/annurev-med-012017-043208 (2018).2 McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T Cell Exhaustion During ...
近日，来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology上发表题为CD8+ T cell differentiation and dysfunction in cancer 的综述。本综述总结回顾了CD8+T细胞在肿瘤中的分化与功能障碍。CD8+T细胞可以选择性杀死肿瘤细胞。肿瘤相关抗原包括肿瘤因突变...
1 Hashimoto, M. et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.Annual review of medicine69, 301-318, doi:10.1146/annurev-med-012017-043208 (2018). 2 McLane, L. M., Abdel-Hakeem, M....
近日,来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology上发表题为CD8+ T cell differentiation and dysfunction in cancer的综述。本综述总结回顾了CD8+T细胞在肿瘤中的分化与功能障碍。
CD8+ T-cell exhaustion in cancer: mechanisms and new area for cancer immunotherapy. Immunotherapies have emerged as the most promising area in cancer treatments in recent years. CD8~+ T cells, as one of the primary effector cells of antica... QF He,Y Xu,J Li,... - Brief Funct Genomics...
近日，来自美国宾夕法尼亚大学的E. John Wherry带领团队在Science Immunology杂志以 In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40 发表了他们最新的研究成果，他们建立一种体外T细胞模型，能够很好的模拟慢性感染或者癌症引起的T细胞耗竭生物学功能，他们将这种...