2024年1月18日,两位华人学者团队在Nature Immunology发表了题为“The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates”的文章。 抗原刺激下,CD8+ T细胞可分化为效应性T细胞和记忆性T细胞,其中记忆性T细胞能够快速高效地产生再次免疫应答。根据记忆性T细胞的表面标志物...
其实很正常,之前我们组建了CD4和CD8的T细胞的交流群就探讨失败,虽然说CD8 T和CD4 T细胞亚群 是一种分类方法,但是各自内部又是可以按照功能进行划分,naive, memory ,effector,cytotoxic,Exhaustion。 比如2022的nature文章:《Androgen receptor activity in T cells limits checkpoint blockade efficacy》,该研究的单细胞数...
Central memory cells (TCM CD62L+ CCR7+) and their precursors, stem central memory T-cells (TSCM) possess the stem-like properties needed to reconstitute and prolong an effective immune response long-term. These cells have been shown to significantly improve therapeutic efficacy of adoptive T-...
又称为记忆性前体细胞（precursors of memory T cells, TMP），具有存活优势，其生存下来，并进一步分化为不同的记忆性T细胞亚类，包括位于淋巴组织的中央记忆细胞（central memory, TCM），在外周血液与组织之间循环的效应记忆细胞（effector memory, TEM）以及定居于外周组织的组织驻留记忆细胞（tissue resident memory...
虽然说CD8 T和CD4 T细胞亚群 是一种分类方法,但是各自内部又是可以按照功能进行划分,naive, memory ,effector,cytotoxic,Exhaustion。比如2022的nature文章:《Androgen receptor activity in T cells limits checkpoint blockade efficacy》,该研究的单细胞数据集里面总共是1.6万个单细胞,然后是提取里面的T细胞后仍然还有1....
CD8+ T cells central memory stemness T cell factor 1 (Tcf1) (Tcf7) effector differentiation Granzyme LCMV infection vaccination Introduction Infection activates very rare antigen-specific naive CD8+ T cells (Tn), which expand and differentiate into cytotoxic effector cells (Teff) that clear pathoge...
Whereas effector memory (EM) T cells (CD62LloCCR7neg) quickly express effector functions upon restimulation and preferentially migrate to tissues and spleen, central memory (CM) T cells (CD62LhiCCR7pos) have hybrid properties of both nave (N) and effector cells. Like N cells, their adhesion...
et al. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc. Natl Acad. Sci. USA 109, 19739–19744 (2012). Article CAS PubMed PubMed Central Google Scholar Ariotti, S. et al. Skin-resident memory CD8+ T cells trigger a state ...
Opposite to low responders, high responders were characterized by enhanced antibody-neutralizing activity, increased frequency of central memory T cells and durable S-specific CD8+ T cell responses. Reduced binding antibodies titers combined with long-term specific memory T cells that had distinct poly...
机译:体外产生CD8〜+ T中央记忆细胞 获取原文 获取原文并翻译|示例 获取外文期刊封面目录资料 开具论文收录证明 >> 文献代查 >> 文献数据库(团队版) >> 摘要 Naive CD8~+ T cells differentiate into effector CTL after Ag encounter.Although induction and persistence of central memory cells are critical ...