Central memory cells (TCM CD62L+ CCR7+) and their precursors, stem central memory T-cells (TSCM) possess the stem-like properties needed to reconstitute and prolong an effective immune response long-term. These cells have been shown to significantly improve therapeutic efficacy of adoptive T-...
Central memory thus derives from stem-cell-like cells that are present during the effector response. Results Tcf7 Expression Identifies Rare Effector-Phase CD8+ T Cells That Resemble Tcm Cells To track the development of Tcm cells, we determined the expression of the transcription factor Tcf1 (...
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate secondary effector CD8+ T cells and to clear p
Role of IL-15 transpresentation in memory CD8+ T-cell responses. It was found that transpresented IL-15 is required for optimal recall responses by memory CD8+ T-cells. In pursuing this further, TCM CD8+ T-cells ... AI Kokaji - University of Alberta (Canada). 被引量: 0发表: 2008年...
Surgical removal of the persisting tumors from the host restored the functional characteristics of memory CD8 + T cells, preventing tumor recurrence after surgery till end of the experiment. Moreover, we observed that generation of superior TCM cells in NLGP treated surgically removed tumor hosts ...
Central memory T cells (Tcm) and stem cell-like memory T cells (Tscm) are known to promote sustained proliferation and persistence after T-cell therapy, constituting essential preconditions for treatment efficacy. Therefore, we set up a protocol for anti-CD19 CAR T-cell generation aiming at ...
Researchers at Fred Hutchinson Cancer Center and QIMR Berghofer Medical Research Institute have found that calcineurin inhibitors (CNIs), while effective in preventing acute graft-versus-host disease (aGVHD), paradoxically promote the expansion and persistence of alloreactive ...
Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike HLA-DR, CD38 is highly expressed on the T
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells Central memory CD8+T cells ( TCM) and effector memory CD8+T cells ( TEM) are found in humans and mice; however, their relative contributions to host immuni... CA Klebanoff...
PD-1 expression on central and effector memory CD8+ T cells after IT in CD4+ T cell depleted mice. HIV-1 transmission occurs mainly through mucosal tissues. During mucosal transmission, HIV-1 preferentially infects alpha(4)beta(+)(7) gut-homing CCR7(-) C... MM Arta,KT Julia,KG Steven...