Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes. Eur. J. Immunol. 41: 634-644.Hanninen A, Maksimow M, Alam C, Morgan DJ, Jalkanen S. 2011. Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes . Eur. J. Immunol. 41 :...
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate secondary effector CD8+ T cells and to clear p
however, tumor recurrence remains a concern. Central memory CD8+T cells (TCM) play important roles in protection from chronic infection and cancer. Here we find, by single-cell RNA analysis of human breast cancer samples, that although the memory phenotype...
Central memory thus derives from stem-cell-like cells that are present during the effector response. Results Tcf7 Expression Identifies Rare Effector-Phase CD8+ T Cells That Resemble Tcm Cells To track the development of Tcm cells, we determined the expression of the transcription factor Tcf1 (...
Central memory T cells (Tcm) and stem cell-like memory T cells (Tscm) are known to promote sustained proliferation and persistence after T-cell therapy, constituting essential preconditions for treatment efficacy. Therefore, we set up a protocol for anti-CD19 CAR T-cell generation aiming at ...
Role of IL-15 transpresentation in memory CD8+ T-cell responses. It was found that transpresented IL-15 is required for optimal recall responses by memory CD8+ T-cells. In pursuing this further, TCM CD8+ T-cells ... AI Kokaji - University of Alberta (Canada). 被引量: 0发表: 2008年...
Central memory T cells (Tcm) have not previously been characterized in cattle and any other ruminant species. Here we described two phenotypically and functionally different subsets of pathogen-specific memory CD4+ T cells in cattle that survived infection with Mycoplasma mycoides subsp. mycoides small...
A deeper analysis of cell death in CD4 T-cell subsets showed increased cell death in memory cells of immunodiscordant individuals, mainly affecting central memory cells. Immunosenescence was also higher in immunodiscordant individuals albeit unrelated to cell death. The CD8 compartment was similar in ...
Representative plots of central memory (CD28 þ CD95 þ ), effector memory (CD28 À CD95 þ ) and naive (CD28 þ CD95 À ) CD4 þ (c,e) and CD8 þ (d,f) T cells in BAL. Quantification of CD4 þ (e) TCM and TEM cells, CD8 þ TCM and TEM cells (f) in ...
and CD8+ T cells, as well as the CD4+/CD8+ T-cell ratio. Furthermore, this combined therapy increased serum immunoglobulin levels, such as IgA, IgG and IgM [113]. Another meta-analysis (N = 1,389) demonstrated that combining Kang ai injection with platinum-based chemotherapy ...