CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of im...
CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancerTo stratify the heterogeneity of prostate cancer (PCa) with seminal vesicle invasion (SVI) immunologically after radical prostatectomy focusing on the tumor microenvironment. We ...
CD8-positive (CD8+) T cells infiltrating the tumor microenvironment (TME) are considered the key tumor killing cells and main target of the PD-1/L1 axis and have thus been proposed to be predictive of the clinical efficacy of immunotherapy [3, 4]. However, given the heterogeneity and ...
Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients Clinical Cancer Research; IF: 11.500; DOI: 10.1158/1078-0432.CCR-23-0178 内容概要:通过scRNA-seq分析CAR-T细胞治疗中影响治疗效果的因素,发现具有高多功能性、...
研究发现替比夫定可抑制CHB患者外周血病毒特异性Th17细胞水平和IL-22的分泌[7],调节性T细胞(regulatory T cells,Treg)水平亦降低,病毒特异性Treg/Th17细胞比例的显著下降可预测HBeAg血清学转换[8-9]。在使用阿德福韦酯抗病毒治疗过程中,...
Issue DateMay 2022 DOIhttps://doi.org/10.1038/s41577-021-00590-3 Subjects CD8-positive T cells Immunological memory Sections Figures References Abstract References Author information Ethics declarations Additional information Glossary Rights and permissions About this article AdvertisementNature...
近日,我院耳鼻咽喉-头颈外科赵宇教授、任建君副研究员、陈飞教授团队联合我院生物医学大数据中心于浩澎副研究员团队在国际著名生物学综合期刊eLife上发表题为Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma的研究论...
Merz H,Lange K,Koch BU,et al.Primary extranodal CD8 positive epitheliotropic T- cell lymphoma arising in a leiomyoma of the uterus.BJOG. 2003Primary extranodal CD8 positive ep itheliotrop ic T-cell lymphoma arising in a leiomyoma of the uterus. MerzH,Lange K,Koch BU,et al. BJOG . 2003...
其中,T淋巴细胞来源于骨髓的多能干细胞,直接参与MTB感染宿主机体的免疫防御。T淋巴细胞先分化为CD4和CD8双阳性T细胞(double positive cell,DP),即CD4+和CD8+T细胞。DP细胞分别经历阳性选择和阴性选择阶段,获取主要组织相容性复合体(major histocompatibility ...
& THORSBY E. (1986) The role of CD8-positive subset of T cells in proliferative responses to soluble antigens. Scand J Immunol 23, 461.Bruserud, O., Sollid, L., Gaudernack, G., and Thorsby, E., 1986, The role of CD8-positive subset of T cells in proliferative responses to ...