Double-positive (DP) CD4~+CD8~+ T cells normally represent a thymic subpopulation that is developed in the thymus as a precursor of CD4~+ or CD8~+ single-positive T cells. Recent evidence has shown that DP cells with an activated phenotype can be tracked in secondary lymph organs. The ...
T Ohteki,R Okuyama,S Seki,... - 《Journal of Immunology》 被引量: 312发表: 1992年 Extrathymic CD4/CD8 double positive T cells Mature T lymphocytes expressing the alphabeta T cell receptor are generally classified as either CD4+ or CD8+, based on the mutually exclusive expression o... ...
+ CD8ß+ (DP) and 2–3% were CD3- CD4- CD8- (triple negative [TN]) and CD19- CD25H CD44+ or CD44-, i.e., comparable to thymocytes at the double negative (DN) DN2 (CD25H CD44+) and DN3 (CD25H CD44-) stages, which can be collectively referred to as pro-pre T cells...
Ishimoto, Y., Tomiyama-Miyaji, C., Watanabe, H., et al., Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+CD8+ cells and B220+ Tcells, in mice,Immunology, 2004, vol. 113, pp. 371–377. Johans...
double negativeautoreactiveWe found that a homogenous CD4-/CD8- T cell bearing an invariant TCR encoded by V±14J±281 with a one-base N-region is highly dominant in the periphery (2-3% in spleen). Surprisingly, the high expression of this invariant V±14 TCR is a general phenomenon in...
T-cell receptor (TCR) αβ+ CD4− CD8− (double-negative; DN) T cells appear in the peritoneal cavity at an early stage of intraperitoneal (i.p.) infection with the intracellular pathogen Listeria monocytogenes. In the present report, we analysed the developmental pathway and fun...
Early thymic progenitors (ETPs), Double-Negative 2 (DN2) cells, Double-Negative 3 (DN3) cells, double positive (DP) thymocytes, and single positive (SP) mature immunocompetent T cells all arise from TSP. Some progenitors may feed directly to downstream stages of thymocyte development without ...
These TD αβ IEL subsets disappeared from the IEL compartment of athymic CRγ−/Y mice, leaving a small population of TCR− IEL that included cells expressing c-kit, Thy-1, B220, CD4, and/or CD8αβ but not CD8αα molecules (Oida et al. 2000). A comparative study of TCR−...
et al. TCRab+ CD4- CD8- T cells differentiate extrathymically in an lck- independent manner and participate in early response against Listeria monocytogenes infection through interferon-c production. Immunology 1997; 91(4): 511-519.Kadena T, Matsuzaki G, Fujise S, et al. TCR alpha betaϩ...
Kisielow, Clonal deletion of immature CD4+ CD8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature 351: 150 (1991).Swat W, Ignatowicz L, von Boehmer H, Kisielow P (1991) Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-...