New insights into how tumors neutralize CD8 T cellstext editorEmerging Infectious Diseases
A. Thyroid hormones increase inducible nitric oxide synthase gene expression downstream from PKC-ζ in murine tumor T lymphocytes. Am. J. Physiol. Cell Physiol. 291, C327–C336 (2006). Article PubMed CAS Google Scholar Klecha, A. J. et al. Integrative study of hypothalamus-pituitary-...
Their increase is checked by the immune activity of cytotoxic T cells H. The number of infected cells killed by cytotoxic T cells is proportional to the product of infected cell abundance and cytotoxic cell abundance, where b is the proportionality coefficient, indicating the effectiveness of the ...
et al. Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes. Proc. Natl Acad. Sci. USA 99, 4538–4543 (2002). PubMed PubMed Central Google Scholar Rudd, B. D. et al. Acute neonatal infections ‘lock-in’ a suboptimal CD8+ T cell ...
Moreover, Kupffer cells are able to override DC-driven proliferation of T cells via the production of the prostaglandins PGE2 and 15-deoxy-delta12,14-PGJ2 [42]. Importantly, Kupffer cells are also able to increase the frequency of hepatic Tregs while promoting Treg production of IL10 [44],...
Describe briefly the various ways in which neurons use both plasma membrane proteins and proteins on the endoplasmic reticulum to increase intracellular Ca2^+ concentrations. Describe the hypothesized steps in the origin of eukaryote cells and the evide...
How do CD8+ T cells become activated by dendritic cells? Briefly describe the differences between cell proliferation and cell differentiation. Why are these two processes crucial in development? Explain the three processes that must take place for a cell to migrate. Be sure to state the key pr...
Thus, the application of the autophagy inhibitor hydrochloroquine (HCQ) was able to re-sensitize resistant cells to BRAFi [53,59]. Furthermore, an excessive increase in ER stress-mediated autophagy can lead to cancer cell death [60]. HA15, a thiazole benzenesulfonamide-based compound that ...
Antigen recognition via interactions between the T-cell antigen receptor (TCR) and peptide major histocompatibility complex (pMHC) molecule is essential for T-cell activation, differentiation, proliferation, and function1. Mechanical forces applied to αβTCR via engaged pMHC substantially increase antigen...
Epidermal RANKL controls regulatory T cell numbers via activation of dendritic cells. Nat. Med. 12, 1372–1379 (2006). CAS PubMed Google Scholar Yamazaki, S. et al. CD8+CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J. Immunol. 181, 6923–6933 (...