PD-1和LAG-3是表达在T细胞表面的抑制性受体,针对PD-1和LAG-3的抗体已经成为癌症治疗的重要组成部分,它们通过激活受体抑制T细胞增殖、细胞因子的产生和细胞毒性活性,进而通过促进对肿瘤的免疫反应来抑制肿瘤发展。 2024年8月发表在cel...
We previously found that the PD-1/PD-L1 pathway is required for CD8 T-cell tolerance in this model. However, the cell population that must express PD-1 and the role of other inhibitory molecules were unknown. Here, we report that LAG-3 is required for long-term peripheral CD8 but not ...
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. LAG-3, TGF-b, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with ...
此外尽管PD-1+ CD4+ T细胞和PD-1+ CD8+ T细胞一样增长,但是FoxP3(Treg标志性分子)+ CD4+ Treg总数在治疗后没有增加,而且整体FoxP3+ Treg数是下降的,提示了治疗降低了Treg的活化。另外和LAG3+ PD-1+ CD8+ T细胞相反,LAG3+ PD-1+ CD4+ T细胞数目并没有增加,也提示了Pegilodecali主要是启动CD8+ T...
In contrast, during chronic infection, PD-1, LAG-3, and 2B4 remained highly expressed, and especially for PD-1 and 2B4, the expression increased on virus-specific CD8+ T cells after day 8 (Figures 4A and 4B). Thus, expression of inhibitory receptors is not unique to chronic viral ...
Fibrinogen-like protein 1 (FGL1)—Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1). However, the prognostic significance of FG
揭示PD-1和LAG-3促进耗竭性CD8+T细胞的协调作用,为抑制性受体的联合作用提供理论基础和研究范例,并指导临床抗感染和抗肿瘤的治疗策略。
CD8+T细胞PD-1或/和LAG-3敲除并不影响小鼠的基础免疫状态。在B16-F10荷瘤条件下,与WT小鼠相比,CD8ΔPD-1敲除小鼠肿瘤轻微变小,但其效果并没有在联合LAG-3敲除后进一步增强。流式分析表明CD8ΔPD-1以及CD8ΔPD-1/LAG-3小鼠肿瘤浸润CD8+T细胞数量和频率增多。有意思的是,当使用B16-gp100细胞系荷瘤时,尽管...
在慢性感染和肿瘤中,持续的抗原刺激诱导T细胞耗竭 【1】 。 T ex 的标志是TOX驱动的独特转录和表观状态以及多种 抑制性受体 (inhibitory receptors, IRs ) 的持续表达,如PD-1、LAG-3、CTLA-4和TIM3等 【2,3】 。 目前,多种IRs为靶点的 免疫检查点阻断疗法 (immune checkpoint blockade, ICB ) 在肿瘤治...
LAG-3, TGF-beta, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L... C.,L.,Lucas,... - 《Blood》 被引量: 39发表: 2011年 LAG-3, TGF-{beta}, and cell-intrinsic PD-1 inhibitory pathways contribute ...