Carbamazepine is a cytochrome P450 3A4 inducer and can decrease the plasma concentration of albendazole, alprazolam, aprepitant, aripiprazole,atorvastatin, bromperidol, buprenorphine, bupropion, calcium channel blockers (e.g. felodipine), cerivastatin, ciclosporin, citalopram, clozapine, corticosteroids (...
Carbamazepine is a potent inducer of hepatic CYP3A4 and is also known to be an inducer of CYP1A2, 2B6, 2C9/19 and may therefore reduce plasma concentrations of co-medications mainly metabolized by CYP 1A2, 2B6, 2C9/19 and 3A4, through induction of their metabolism. When used concomi...
Carbamazepineis extensively metabolized in the liver. After a single dose,t½,elimin plasma is around 30–40h, but because of “autoinduction” (carbamazepine induces its own metabolism),t½,elimmay fall to around 12h after long-termmonotherapy. Carbamazepine, as a potent enzyme inducer, is...
When carbamazepine is added to an existing anticonvulsant regimen, introduce the drug gradually while maintaining or gradually decreasing dosage of other anticonvulsant(s); certain enzyme-inducing anticonvulsants (e.g., phenytoin) may require an increase in dosage. (See Specific Drugs, Foods, and ...
Human microsomal epoxide hydrolase has been identified as the enzyme responsible for the formation of the 10, 11-transdiol derivative from carbamazepine-10, 11 epoxide. After oral administration of 14C carbamazepine, 72% of the administered radioactivity was found in the urine and 28% in the feces...
Carbamazepine is a potent inducer of hepatic 3A4 and is also known to be an inducer of CYP1A2, 2B6, 2C9/19 and may therefore reduce plasma concentrations of co-medications mainly metabolized by CYP 1A2, 2B6, 2C9/19 and 3A4, through induction of their metabolism. When used concomitant...
Pharmacokinetic and Metabolic Investigation of Topiramate Disposition in Healthy Subjects in the Absence and in the Presence of Enzyme Induction by Carbama... Summary: Purpose: To characterize the metabolic profile of topiramate (TPM) in humans and to assess the influence of enzyme induction by c...
Venlafaxine is a weak inhibitor of CYP2D6 and no clinically significant interactions involving this enzyme have been reported.Theoretically, a pharmacokinetic interaction could occur between carbamazepine and venlafaxine because of the induction properties of carbamazepine and the partially common metabolic ...
Ticagrelor is contraindicated in combination with cytochrome P450 3A4 and 3A5 enzyme (CYP3A4/5) inducers due to increased clearance, causing diminished antiplatelet effects. The emergent nature of acute coronary syndromes (ACS) may preclude scrutinization of home medications before P2Y12 inhibitor admin...
Human microsomal epoxide hydrolase has been identified as the enzyme responsible for the formation of the 10,11-transdiol derivative from carbamazepine-10,11 epoxide. Coadministration of inhibitors of human microsomal epoxide hydrolase may result in increased carbamazepine-10,11 epoxide plasma concentration...