Carbamazepine is an anticonvulsant used to control tonic-clonic and partial seizures. It is extensively metabolized in the liver, the primary metabolite carbamazepine-10,11-epoxide retaining approximately one third of the antiepileptic activity of carbamazepine. Carbamazepine is a hepatic enzyme inducer of...
Carbamazepine is metabolized in the liver, and there is evidence that its continued administration leads to hepatic enzyme induction. Carbamazepine- 10,11-epoxide is a pharmacologically active metabolite with significant anticonvulsant effects of its own. General Description Certified pharmaceutical secondary ...
Carbamazepine is metabolized in the liver. Cytochrome P450 3A4 was identified as the major isoform responsible for the formation of carba mazepine-10,11-epoxide from carbamazepine. Human microsomal epoxide hydrolase has been identified as the enzyme responsible for the formation of the 10,11-trans...
activity and potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also acts as an in vitro inducer of CYP3A4, the main human metabolizing enzyme present in the liver and ...
Conversely, co-administration of phenytoin or phenobarbital, both microsomal enzyme inducers, can increase the metabolism of carbamazepine, potentially resulting in subtherapeutic plasma levels. Carbamazepine has also been associated with bone marrow suppression, and its combination with other agents that ...
Carbamazepine is metabolized in the liver. Cytochrome P450 3A4 was identified as the major isoform responsible for the formation of carbamazepine-10, 11-epoxide from carbamazepine. Human microsomal epoxide hydrolase has been identified as the enzyme responsible for the formation of the 10, 11-trans...
Human microsomal epoxide hydrolase has been identified as the enzyme responsible for the formation of the 10,11-transdiol derivative from carbamazepine-10,11 epoxide. Coadministration of inhibitors of human microsomal epoxide hydrolase may result in increased carbamazepine-10,11 epoxide plasma concentration...
Serious side effects include dangerously low red and white blood cell counts. Severe skin reactions can occur as well as serious liver abnormalities, such as hepatitis, resulting in jaundice. Low sodium levels and thyroid abnormalities have been described. ...
CBZ is a potent enzyme inducer [15,16]. Predicting when CBZ dosage assessment is required mandates a useful working knowledge of drug induction; any health care professional in epilepsy will be very clear on relevant drug interactions, whilst other health care teams may find this complex. As ...
Carbamazepine is primarily metabolized in the liver. CYP3A4 was identified as the major isoform responsible for the formation of carbamazepine-10,11-epoxide. Human microsomal epoxide hydrolase has been identified as the enzyme responsible for the formation of the 10,11-transdiol derivative from carbam...