Carbamazepine is a cytochrome P450 3A4 inducer and can decrease the plasma concentration of albendazole, alprazolam, aprepitant, aripiprazole,atorvastatin, bromperidol, buprenorphine, bupropion, calcium channel blockers (e.g. felodipine), cerivastatin, ciclosporin, citalopram, clozapine, corticosteroids (...
Carbamazepineis extensively metabolized in the liver. After a single dose,t½,elimin plasma is around 30–40h, but because of “autoinduction” (carbamazepine induces its own metabolism),t½,elimmay fall to around 12h after long-termmonotherapy. Carbamazepine, as a potent enzyme inducer, is...
Although a single administration of CBZ did not affect the plasma ALT levels, even when cotreated with BSO, pretreatment with dexamethasone, a CYP3A inducer, increased the plasma ALT levels. In addition, the rats cotreated with troleandomycin or ketoconazole, CYP3A inhibitors, suppressed the ...
Manufacturer of carbamazepine injection states the drug generally should not be used in patients with moderate or severe renal impairment.Common Adverse EffectsDizziness, drowsiness, unsteadiness, nausea, vomiting.Drug InteractionsMetabolized by CYP3A4. Potent inducer of CYP3A4; also induces CYP1A2, 2...
Carbamazepine is a potent inducer of hepatic CYP3A4 and is also known to be an inducer of CYP1A2, 2B6, 2C9/19 and may therefore reduce plasma concentrations of co-medications mainly metabolized by CYP 1A2, 2B6, 2C9/19 and 3A4, through induction of their metabolism. When used concomi...
This phase 1, open‐label, single‐sequence, drug‐drug interaction study evaluated the pharmacokinetics, safety, and tolerability of a single oral dose of erdafitinib alone and when co‐administered with steady state oral carbamazepine, a dual inducer of CYP3A4 and CYP2C9, in 13 h...
Carbamazepine is a potent inducer of hepatic 3A4 and is also known to be an inducer of CYP1A2, 2B6, 2C8/9/19, and may therefore reduce plasma concentrations of co-medications mainly metabolized by CYP 1A2, 2B6, 2C8/9/19, and 3A4, through induction of their metabolism. When used ...
Carbamazepine is a potent inducer of hepatic 3A4 and is also known to be an inducer of CYP1A2, 2B6, 2C9/19 and may therefore reduce plasma concentrations of co-medications mainly metabolized by CYP 1A2, 2B6, 2C9/19 and 3A4, through induction of their metabolism. When used concomitant...
CBZ is a powerful inducer of hepatic enzymes (including both hetero and auto-induction) and is extensively metabolized in the liver (primarily by CYP3A4), causing numerous clinically relevant drug-drug interactions [52] (Table 5). Auto-induction, in particular, results in nonlinear, time-depende...
The purpose of this study is to estimate the effect of carbamazepine, a strong CYP3A4 inducer, on the pharmacokinetics (PK) of ibuzatrelvir in healthy participants. This study is seeking participants who: * are male or female that are not of childbearing potential of 18 years of age or ...