Mechanism of action Studies have shown that carbamazepine exerts its therapeutic effects by modulating voltage-gated sodium channels (VGSC). It does this by binding to the alpha subunit of the VGSC, which in turn causes the channel to become inactivated, thereby inhibiting the generation of action...
Carbamazepine increases atherogenic lipopro- teins: mechanism of action in male adults. Heart Circ Physiol 2002;282:704--16.Bramswig S, Kerksiek A, Sudhop T, Luers C, Von Bergmann K, Berthold HK. Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. Am J ...
Biochemical effects of carbamazepine. Relationship to its mechanism of action in affective illness . Prog. Neuropsychopharmacol. Biol. Psychiat. , 7 , 263 – 271 .Post RM, Uhde TW, Rubinow DR, Ballenger JC, Gold PW (1983c). Biochemical effects of carbamazepine, relationship to its mechanisms ...
It is widely used as an antiepileptic drug for the treatment of simple and complex partial tonic-clonic seizures. Biochem/physiol Actions Anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Sodium channel inhibitor. Mechanism of action In animals, the profile of antiseizure ...
Carbamazepine is chemically unrelated to other anticonvulsants or other drugs used to control the pain of trigeminal neuralgia. The mechanism of action remains unknown. The principal metabolite of carbamazepine, carbamazepine-10,11-epoxide, has anticon vulsant activity as demonstrated in several in vivo...
Experts believe that carbamazepine works by dampening down electrical impulses and reducing the subsequent firing of the nerve; however, the exact mechanism of action is unknown. Carbamazepine is not chemically related to any other available anticonvulsant or medicine used in the treatment of nerve diso...
though the drug’s essential mechanism of action at the molecular level was unclear. The latter has now been elucidated, and considerable additional information has become available concerning the disposition, interactions and toxicity of the drug, mainly in humans, whilst its range of therapeutic use...
How does carbamazepine work (mechanism of action)? Carbamazepine works for both seizures and trigeminal neuralgia by balancing signals between nerves. How is carbamazepine supplied (dosage forms)? Carbamazepine is available as Carbatrol, Epitol, Tegretol, Tegretol XR, and generic carbamazepine in the...
is derived from clinical investigations performed in adults and from studies in several in vitro systems which support the conclusion that (1)thepathogenicmechanisms underlying seizure propagation are essentially identical in adults and children, and (2) the mechanism of action of carbamazepine in treati...
摘要: Summary This chapter contains section titled: Mechanism of action Pharmacokinetics Clinical efficacy Side-effects Pharmacoeconomic aspects Quality of life Clinical therapeutics关键词: carbamazepine pharmacokinetics breast milk moistured tablets elimination ...