Summary This chapter contains sections titled: History Mode of action Clinical studies Principal indications Pharmacokinetics and metabolism Interactions Side-effects Practical aspects Key points ReferencesDr. Jean-Michel Aubry psychiatrist psychotherapist
Since there have been reports of cholestatic hepatitis in neonates exposed to carbamazepine during antenatal and or during breastfeeding, breastfed infants of mothers treated with carbamazepine should be carefully observed for adverse hepatobiliary effects. Mode of action The many effects of CBZ on the...
Deupree J.D.: Mode of action of anticonvulsant drugs: Membrane effects, in The Treatment of Epilepsy, J. H. Tyrer, ed., pp. 1–28, J. B. Lippincott, Philadelphia, 1980. Google Scholar Domenjoz, R. and Theobald, W.: Zur Pharmakologie des Tof ranil. (N-(3-di-methyl-aminopropy1...
摘要: Summary This chapter contains sections titled: History Mode of action Clinical studies Principal indications Pharmacokinetics and metabolism Interactions Side-effects Practical aspects Key points References关键词: carbamazepine (CBZ) in manic phases association lithium–CBZ CBZ activating cytochrome P450 ...
Mode of Administration Carbamazepineis normally given orally but can also be administered by suppository. Pharmacological Effects Carbamazepinereduces the spread of impulses fromepileptic foci. It also increases the activity ofcytochromeP450 in the liver (enzyme induction) and may thus reduce the plasma ...
Carbamazepine's mode of action in mania is unknown, but a variety of effects on receptors, neurotransmitters, ion channels and binding sites have been documented. It has a complex pharmacokinetic profile due to autoinduction and a long-acting active metabolite. Carbamazepine's most frequent adverse...
Definition (MSH)An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure ...
Han et al. (2018) reported that the cytotoxicity and genotoxic effects of the anti-seizure drug carbamazepine during chloramination, ozonation and chlorination centered on the mode of action. The study showed that the ozonation process caused significant chromosome damage and cytotoxicity in CHO-K1 ...
4-Aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addit... H Olpe,CN Kolb,A Hausdorf,.....
In: Schroder P, Collins C (eds) Organic xenobiotics and plants: from mode of action to ecophysiology. Springer, Dordrecht, Heidelberg, London, New York, pp 3–16 Chapter Google Scholar Dordio AV, Belo M, Teixeira DM, Carvalho AJP, Dias CMB, Pico Y, Pinto AP (2011) Evaluation of ...