Which of the following is an example of enzyme inducer? Examples of enzyme inducers includeaminoglutethimide, barbiturates, carbamazepine, glutethimide, griseofulvin, phenytoin, primidone, rifabutin, rifampin, and troglitazone. Some drugs, such as ritonavir, may act as either an enzyme inhibitor or...
Is phenytoin an inducer or inhibitor? Phenobarbital, phenytoin, primidone and carbamazepine are potent inducers of cytochrome P450 (CYP), epoxide hydrolase and uridine diphosphate glucuronosyltransferase (UDPGT) enzyme systems; oxcarbazepine is a weak inducer of CYP enzymes, probably acting on a few ...
Abemaciclibc Carbamazepine CYP3A 0.20 N/P [7] Brigatinibc Rifampin CYP3A4, CYP2C8 0.20 0.40 [32] Netupitant Rifampin CYP3A4 0.20 0.45 [33] IV, intravenously; ACP-5862, acalabrutinib hydroxylated metabolite. a Also metabolized by CYP1A2, CYP2C9, and CYP2C19, and rifampin is an ind...
An understanding of which CYP-450 isoenzyme is responsible for the metabolism of a drug is essential for trying to predict and understand the magnitude of drug interactions. Some drug-metabolism inhibitors are highly selective for certain CYP isoenzymes. Drugs that are highly selective enzyme inhibito...
Drug Interactions In evaluating the potential for interactions among co-administered antiepilepsy drugs (AEDs), whether or not an AED induces or does not induce metabolic enzymes is an important consideration. Carbamazepine, phenytoin, primidone, and phenobarbital are generally classified as enzyme ...
Strong CYP3A4 inducer drugs rifampin,carbamazepine, St. John’s wort, or long-actingbarbiturates, because these can significantly reduce the concentration of isavuconazole and reduce its efficacy. Inclinical trials, isavuconazole caused disturbances in theheartrhythm by shortening the QTc interval. Do ...
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