Examples of enzyme inducers includeaminoglutethimide, barbiturates, carbamazepine, glutethimide, griseofulvin, phenytoin, primidone, rifabutin, rifampin, and troglitazone. Some drugs, such as ritonavir, may act as either an enzyme inhibitor or an enzyme inducer, depending on the situation. Is rifamp...
Letermovir is an inducer of CYP2B6 in vitro; the clinical relevance is unknown. Letermovir inhibited efflux transporters P-gp, breast cancer resistance protein (BCRP), bile salt export pump (BSEP), multidrug resistance-associated protein 2 (MRP2), OAT3, and hepatic uptake transporter OATP1B1/3 ...
Stimulation of retinoic acid-induced functional sodium iodide symporter (NIS) expression and cytotoxicity of (1)(3)(1)I by carbamazepine in breast cancer cells. Breast Cancer Res Treat 2011; 125: 377–386. Article CAS Google Scholar Dentice M, Luongo C, Elefante A, Romino R, Ambrosio R...
This result is likely due to the concurrent inhibition of hepatic uptake by rifampin, a known inhibitor of organic anion transporting polypeptide (OATP) transporters. In comparison, concomitant use of efavirenz, a moderate inducer of CYP3A that does not affect OATPs, decreased simeprevir AUC and ...
Strong CYP3A4 inhibitordrugssuch asketoconazoleor high-doseritonavir, because these can increase the concentration of isavuconazole and the risk for toxicity and adverse effects. Strong CYP3A4 inducer drugs rifampin,carbamazepine, St. John’s wort, or long-actingbarbiturates, because these can signifi...
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an interaction by being a competitive inhibitor. Obviously, if it is known that a new drug is metabolized by a specific CYP isoenzyme system, it is logical to assume that the new drug will exhibit drug interactions with known inducers and inhibitors of specific CYP isoenzymes. Management of ...
Stimulation of retinoic acid- induced functional sodium iodide symporter (NIS) expression and cytotoxicity of (1)(3)(1)I by carbamazepine in breast cancer cells. Breast Cancer Res Treat 2011; 125: 377–386. 34. Dentice M, Luongo C, Elefante A, Romino R, Ambrosio R, Vitale M et al. ...