Endogenous binding of HDAC3 to HRE was not affected by CF6 at 30 min (Figure 2c), suggesting that HRE is specific to the CF6-induced HIF-1a pathway but not to the c-Src pathway. Effect of CF6 on hypoxia-induced apoptosis in HUVECs The percentage of apoptotic cells was slightly but ...
The aim of the present study was to evaluate the involvement of c-Src in AT2 receptor signaling pathway during rat development in hindbrain (PDN15) and fetal (E20) membrane preparations. Aliquots (500 μg) of membranes were stimulated with Ang Ⅱ in presence or not of competitors and the ...
IL-6 signal activates c-Src through the IGFBP5 pathway. We next asked whether IL-6 could impact c-Src, thus creating a loop of regu- lation. To this purpose, we treated primary mouse osteoblasts with hrIL-6 and observed a time-dependent increase in the phosphor- ylation of c-Src Y-...
Taken together, the present study demonstrate, for the first time, that PTH rapidly and transiently stimulates PI3K activity and its down effector Akt/PKB in rat enterocytes playing c-Src kinase a central role in PTH-dependent PI3K activation and that PI3K signaling pathway contributes to PTH-...
Identification of β-Escin as a Novel Inhibitor of Signal Transducer and Activator of Transcription 3/Janus-Activated Kinase 2 Signaling Pathway that Suppr... Indeed, we found that beta-escin induced the expression of tyrosine phosphatase Src homology phosphatase 1 that correlated with the down-reg...
1978 年第一个致癌基因劳斯氏肉瘤病毒(Rous sarcoma virus, v-Src) 的转化因子被证实是一种蛋白激酶。
The PGI2 signaling pathway follows the NO pathway through release of [Ca2+]i, but diverges prior to NOS activation and also requires activation of mitogen-activated protein kinase. These results suggest that NO and PGI2 function in parallel in mediating the effects of VEGF....
(ERK) pathway is also needed for the induction of i-LTP. Accordingly, its inhibition by PD 98059 could prevent this form of pathological synaptic plasticity (Calabresi et al., 2001b, 2002). Interestingly, both LY 367385 and, in a larger extent, PD 98059, could reduce the activation of ...
当HGF与c-Met结合时，细胞内酪氨酸激酶结构域的Tyr-1234和Tyr-1235发生自动磷酸化，导致C末端对接位点Tyr-1349和Tyr-1356的自动磷酸化。这有助于细胞内效应分子的招募，如生长因子受体结合蛋白2(Grb2)、SRC、PI3K和GAB1，从而激活下游信号通路。Shawna and Tsao, Therapeutic Advances in Medical Oncology 02 c...
The N-terminal region of c-Src, including the SH4 and Unique domains, was found by NMR to display a partially structured section between residues 60–64 and 67–7417. Here we show that this region includes a new lipid binding site, in addition to the SH4 domain, with affinity for ...