Src/FAK pathwayBreast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the ...
Src、FAK、PI3K、ERK、AKT Receptoractivation press EGF、PDGFR···RTKs SrcFAK sos Ras-GTP sosGrb2 Src-DependentFAK-AktPATHWAY PI3K-AKTPATHWAY ERK1/2 PATHWAY PI3K c-Raf PIP2PIP3 RALGDS MEK1/2 AKT/PKB BAD GEFIKK ···ERK1/2ELK-1···CASPASE9 AFX RAC1 NFκBExpressionofanti-apoptotic...
Subsequent mechanistic studies showed that LOXL2 could activate both the Snail/E-cadherin and Src kinase/Focal adhesion kinase (Src/FAK) pathways. However, secreted LOXL2 induced gastric tumor cell invasion and metastasis exclusively via the Src/FAK pathway. Expression correlation analysis in gastric ...
FAK Src β 3 integrin Ras-GTP ERK1/2 PATHWAY PI3K PI3K-AKTPATHWAY c-Raf MEK1/2 ERK1/2 ELK-1··· AKT/PKB PIP 2 PIP 3 GEF RAC1 NFκB IKK Expressionof anti-apoptotic genes BAD CASPASE9 AFX BCL-XL CASPASE CASCADE PATHWAY FasLigand Expression ApoptosisAnti-Apoptosis celldifferentiation ...
PI3K-AKT PATHWAY,c-Raf,MEK1/2,ERK1/2,ELK-1 ,RALGDS,AKT/PKB,PIP2,PIP3,GEF,RAC1,NFB,IKK,Expression of anti-apoptotic genes,BAD,CASPASE9,AFX,BCL-XL,EGF、PDGFR,CASPASE CASCADE PATHWAY,Fas Ligand Expression,Apoptosis,Anti-Apoptosis,cell differentiation,Src,Src-Dependent FAK-Akt PATHWAY,3 ...
分子调节这些过程的机理建立在Src和FAK的反应的基础上。Src与粘附分子有关。Src的磷酸化使得在粘附分子上 的整联蛋白受体接收的黏着性与转移信号得以传播。Src的作用靶点一般来说就目前的研究而言,src的作用靶点有以下几类:第一种是以src激酶为作用靶点。 4、到目前为止还没有被批准的 src激酶抑制剂,但是新的分子...
Indeed, the cancer stem cell marker, CD133, can interact and activate Src, which through the phosphorylation of FAK contributes to cancer stem cell migration [50]. At least two signalling pathways responsible for maintaining the stemness are related to Src activity in non-small cell lung cancer...
Ｓｒｃ蛋白激酶的研究进展 陈㊀烨∗ꎬ王㊀智ꎬ傅浩栋ꎬ车㊀晋 (辽宁大学药学院ꎬ辽宁沈阳１１００３６)摘㊀要:类固醇受体辅激活因子(ＳｔｅｒｏｉｄｒｅｃｅｐｔｏｒｃｏａｃｔｉｖａｔｏｒꎬＳｒｃ)是一种由Ｓｒｃ原癌基因编码的非受体型酪氨酸激酶ꎬ属于Ｓｒｃ家族蛋白激酶(Ｓｒｃ￣ｆａｍｉｌｙｋｉ...
IL-1b activated focal adhesion kinase (FAK) and proto-oncogene tyrosine-protein kinase Src (Src). Moreover, inhibiting the Src/FAK pathway reduced the IL-1b-induced production of MMP-9 and cell invasion. To investigate the functional role of FAK in MMP-9 production cell lines expressing ...
Src 及其信号通路在肿瘤发生过程中的作用