Dasatinib and KX2-391, inhibitors of the Src/FAK pathway, significantly increased the sensitivity of HepG2/DOX cells to DOX. The results suggest that Src/FAK is a downstream regulator of Cx32 and Cx32 regulates the sensitivity of HCC cells to DOX via the Src/FAK signaling pathway. Our ...
Src 及其信号通路在肿瘤发生过程中的作用
摘㊀要:类固醇受体辅激活因子(ＳｔｅｒｏｉｄｒｅｃｅｐｔｏｒｃｏａｃｔｉｖａｔｏｒꎬＳｒｃ)是一种由Ｓｒｃ原癌基因编码的非受体型酪氨酸激酶ꎬ属于Ｓｒｃ家族蛋白激酶(Ｓｒｃ￣ｆａｍｉｌｙｋｉｎａｓｅｓꎬＳＦＫｓ)的核心成员.Ｓｒｃ广泛存在于人体细胞中ꎬ可调节细胞分裂㊁运动㊁黏附㊁血管生成和存活...
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 2015;5:10194. Article CAS PubMed PubMed Central Google Scholar Liu C, Li Y, Xing Y, Cao B, Yang F, Yang T, et al. The interaction ...
These studies also shed light on the role of focal adhesion kinase (FAK) downstream of v-Src and other signaling pathways in controlling migration, invasion and survival of transformed cells. Src directly phosphorylates integrins and can also modulate R-Ras activity. Moreover, it stimulates the E...
Catalpol ameliorates liver fibrosis inhibiting aerobic glycolysis by EphA2/FAK/Src signaling pathway 厌氧糖酵解 原癌基因酪氨酸蛋白激酶Src 化学 肝纤维化 糖酵解 梓醇 信号转导 EPH受体A2 生物化学 细胞生物学 纤维化 癌症研究 药理学 医学 生物 内科学 酶 受体酪氨酸激酶 有机化学 糖苷 ...
Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression o
Constitutive activation of FAK/Src signaling promotes the growth and metastasis of ovarian cancer. RSPOs have been shown to potentiate the Wnt/β-catenin signaling pathway in a variety of cancers (Ter Steege and Bakker, 2021), but whether RSPOs crosstalk with other intracellular signaling pathways...
(CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins,...
Interfering with upstream and/or downstream molecules of the SRC signaling pathway Given the complexity of the SRC signaling network, therapeutic agents aimed at interfering with upstream and/or downstream SRC signaling components (e.g., integrins, EGFR, FAK, PI3K) represent another promising approach...