We previously show that ouabain induces autophagic cell death in human lung cancer cells by regulating AMPK-mediated mTOR and Src-mediated ERK1/2 signaling pathways. However, whether and how AMPK and Src signaling interacts in ouabain-treated cancer cells remains unclear. Given the pivotal role of...
Src 及其信号通路在肿瘤发生过程中的作用
In addtion, the change level of Hela cell, p-ERK 1/2 and c-Fos protein were lower than that of C33A cell before and after the Src inhibition. ConclusionsSrc, involved in regulating the expression of key factors of the ERK signal transduction pathway including p-ERK 1/2 and p-c-Fos, ...
Conclusion: CsA enhances the invasion and down-regulates the E-cadherin expression of JEG-3 cells through activation of Src signaling pathway, which suggests Src signaling pathway may be involved in the favorable modulation by CsA in human trophoblast cells. Key words: cyclosporin A (CsA); ...
Src is a node of several signals involved in many of these biological processes, and it is also an important regulator of cell metabolism. Glucose uptake, glycolysis, the pentose-phosphate pathway and oxidative phosphorylation are among the metabolic pathways that can be regulated by Src. Therefore...
pathway is required for this translocation. The close correlation between the accumulation of RIP1/RIP3 in heterotypic membranes accumulation and necroptosis suggests the requirement of this translocation in cell death; however, the precise subcellular location into which RIP1/RIP3 necrosomes need to ...
Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating ...
摘㊀要:类固醇受体辅激活因子(ＳｔｅｒｏｉｄｒｅｃｅｐｔｏｒｃｏａｃｔｉｖａｔｏｒꎬＳｒｃ)是一种由Ｓｒｃ原癌基因编码的非受体型酪氨酸激酶ꎬ属于Ｓｒｃ家族蛋白激酶(Ｓｒｃ￣ｆａｍｉｌｙｋｉｎａｓｅｓꎬＳＦＫｓ)的核心成员.Ｓｒｃ广泛存在于人体细胞中ꎬ可调节细胞分裂㊁运动㊁黏附㊁血管生成和存活...
(1∶1 000,Cell signaling公司);t-Src抗体(1∶1 000,Cell signaling公司);β-actin抗体(1∶10 000,Cell signaling公司);HRP标记山羊抗兔IgG二抗(中杉金桥公司);HRP标记山羊抗小鼠IgG二抗(中杉金桥公司);Trizol试剂(Invitrogen公司);qPCR Super mix(北京全式金生物技术有限公司);RT-PCR引物合成(北京生工生物...
而后,GO以及KEGG通路富集分析发现细胞外基质(ECM)受体互作通路(ECM-receptor interaction pathway)显著富集(图2)。并且,整合素家族基因(integrins)作为一种ECM受体,在耐药细胞系中的表达显著提高,说明该基因参与的通路被异常激活。 图2 Enric...