Doxorubicin-induced HMG-CR downregulation was associated with inactivation of the EGFR-Src pathway. Furthermore, a high-cholesterol-diet attenuated the anti-cancer activity of doxorubicin in a tumor xenograft mouse model. In a multivulva model ofexpressing an active-EGFR mutant, doxorubicin decreased ...
elegans the EGFR pathway participates in the determination of numerous cell fates, including the development of the compound eye and the vulva. The four EGFR orthologs in vertebrates form a layered signaling network that participates in specif i cation of cell fate and coordinates cell proliferation....
EGFR that is constitutively activated in the majority of GBM causes YTHDF2 overexpression through the EGFR/SRC/ERK pathway. EGFR/SRC/ERK signaling phosphorylates YTHDF2 serine39 and threonine381, thereby stabilizes YTHDF2 protein. YTHDF2 is required for GBM cell proliferation, invasion, and ...
Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or ... L Leung,L Chung,I Tam,... - 《Cancer Research》 被引量: 0发表: 2007年 [Molecular targeted therapy--non-small-cell lung cancer an...
ERBB2 signaling pathwayEGF, EGFR, AKT1, GAB1, HRAS, KRAS, NRAS, PIK3CA, PIK3R1, RPS27A, SHC1, SOS1, SRC, UBA52 hsa04151 PI3K-Akt signaling pathwayAKT3, CDKN1A, CDKN1B, THEM4, CREB1, EGF, EGFR, AKT1, AKT2, FGFR1, PHLPP2, FOXO3, FGF22, GSK3B, NR4A1, HRAS, KRAS, MDM2, NRAS...
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J. Cell Biol. 175, 993–1003 (2006). 10. Dans, M. et al. Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated ...
32·2达沙替尼(dasatimb)是一个有效的口服小分子多靶点激酶抑翩剂,可以抑制5种酪氨 Src抑制剂.Haung的实验证实达沙替尼对实体肿瘤包括TNBC在内具有活性团】。而后Finn进行 了采用达沙替尼单药治疗TNBC的lI期临床试验(CAl80059试验)。该试验发现达沙替尼具有对 TNBC治疗的单药活性,临床有效率(pCR)为93%(4/43...
S佗激酶在恶性肿瘤的血管生成、细胞增殖、肿瘤的侵袭转移中具有重要作用,而在TNBC中发现Src激酶和PKB的活性增高州。2EGFR与TNBCEGFR在TNBC中表达率约为60%,其信号传导通路已证实与TNBC的发生发展相关■EOFR在包括TNBC在内的多种人类恶性实体瘤中存在过表达或突变,通过介导多种途径的信号通路调控细胞的生长、分化、...
(Kadmon 子公司) 临床 III 期 Src 家族激酶抑制剂 custirsen sodium 丛生蛋白抑制剂 英国哥伦比亚大学 临床 III 期 美国 acelarin 嘧啶拮抗剂,DNA 合成抑制剂 NuCana BioMed 临床 I,II 期 naquotinib EGFR 抑制剂 安斯泰来 临床 III 期 日本 司美替尼 MEK2/MEK1 抑制剂 Array BioPharm 临床 III 期 紫杉...
Similarly, PTMSigDB analysis for module 2 confirmed the involvement of EGFR1 Pathway while MsigDB detected actin cytoskeleton, ErbB signaling, and focal adhesion pathways. KSEA of module 2 protein-protein network highlights significant activation of SRC, MAP2K1, HCK, LCK, SYK, JAK3, JAK2, FYN,...