EGFR signaling pathway in breast cancers: from tradi- tional signal transduction to direct nuclear translocalization. Breast Cancer Res Treat 2006; 95:211-8.Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. ...
differentiation, apoptosis, signal transduction and immune regulation at the post-transcriptional level. So it has become one of the research hotspots in recent years. Among them, MiR-7 is considered to be an important regulator of
信号通路(signal pathway)的提出最早可以追溯到 1972 年,不过那时被称为信号转换(signal transmission) 。1980 年,M. Rodbell 在一篇综述中 提到信号转导(signal transduction) ,此后这个概念就被广泛使用了。信号通路是指能将细 胞外的分子信号经细胞膜传入细胞内发挥效应的一系列酶促反应通路。 这些细胞外的分子...
获邀担任Cell Research, Signal Transduction and Targeted Therapy, Nature Communications, Science Advances, Cell Reports, Trends in Analytical Chemistry等20余个期刊的审稿人。任国家自然科学基金委面上、重点、海外优青函评及二审,及...
B7-H3 promotes cancer cell survival, invasion, migration, metastasis and drug resistance in various types of cancer that is independent of its immune function by acting upstream from signal transduction pathways, such as PI3K/AKT, JAK2/STAT3, and Raf/MEK/ERK1/2, to induce anti-apoptotic and ...
In fact, several proto-oncogenes code for proteins that are either growth factors, or growth factor receptors, or proteins that are involved in the intracellular signal transduction pathway for growth factors. In addition, activated cellular proto-oncogenes may also control the endogenous production ...
1f). As the EGFR-driven pro-survival pathway is vital to tumour progression, we evaluated the effect of DPBA on EGFR downstream signalling pathway. DPBA significantly down-regulated EGFR protein in EGFR WT and EGFR mutant NSCLC cell lines in a time-dependent manner and did not increase EGFR ...
the viral supernatants were diluted fourfold in fresh medium before transduction. Transduction was carried out in the presence of 5 μg ml−1polybrene, and the medium was changed 12 h later. To isolate the cells that expressed GFP, cells were dissociated into a single-cell suspension ...
signal transduction pathway can regulate cell growth proliferation and differentiation Kinds of mutations in the area of tyrosine kinase have been found in cancer which are highly correlated with the clinical response to tyrosine kinase inhibitor So the detection of EGFR mutations has much reference ...
According to the cell signal transduction pathway, the etiology of EGFR-TKI resistance can be divided into subsequent categories. 2. EGFR mutations induce drug resistance, especially the secondary mutation T790M The EGFR gene, located in the 7p12−14 region in the short arm of chromosome 7, ...