combination therapyMEKgefitinibtumor cell signalingEpidermal growth factor receptor (EGFR) is a protein tyrosine kinase that plays a crucial role in signal transduction pathways that regulate key cellular functions such as survival and proliferation. Since its discovery in 1984, clinical studies have ...
信号通路(signal pathway)的提出最早可以追溯到 1972 年,不过那时被称为信号转换(signal transmission) 。1980 年,M. Rodbell 在一篇综述中 提到信号转导(signal transduction) ,此后这个概念就被广泛使用了。信号通路是指能将细 胞外的分子信号经细胞膜传入细胞内发挥效应的一系列酶促反应通路。 这些细胞外的分子...
EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization 来自 国家科技图书文献中心 喜欢 0 阅读量: 116 作者:HW Lo,SC Hsu,MC Hung 摘要: Aberrant epidermal growth factor receptor (EGFR) signaling is a major characteristic of many human ...
获邀担任Cell Research, Signal Transduction and Targeted Therapy, Nature Communications, Science Advances, Cell Reports, Trends in Analytical Chemistry等20余个期刊的审稿人。任国家自然科学基金委面上、重点、海外优青函评及二审,及...
Subsequently, the EGFR transmits signals to prominent downstream pathways, such as mitogen-activated protein kinases, the phosphoinositide 3-kinase/Akt pathway and modulation of ion channels. Analysis of GPCR-induced EGFR activation in more than 60 human carcinoma cell lines derived from different ...
(Fig.1H). Reactome pathway analysis of protein hits showed preferential interactions between TAD mutants and proteins involved in signal transduction, metabolism, and cellular compartmentalization, while DBD mutants demonstrated increased interactions with typically nuclear proteins involved in transcriptional ...
signal transduction pathway can regulate cell growth proliferation and differentiation Kinds of mutations in the area of tyrosine kinase have been found in cancer which are highly correlated with the clinical response to tyrosine kinase inhibitor So the detection of EGFR mutations has much reference ...
Drosophila oogenesis provides a useful system to study signal transduction pathways and their interactions. Through clonal analysis, we found that brinker (brk), a repressor of Dpp signaling, plays an important role in the Drosophila ovary, where its function is essential for dorsal appendage formatio...
Signal Transduction and Targeted Therapy(2024) TP53 gain-of-function mutations promote osimertinib resistance via TNF-α–NF-κB signaling in EGFR-mutated lung cancer Ritsu Ibusuki Eiji Iwama Isamu Okamoto npj Precision Oncology(2024) Inhibition of proteinase-activated receptor 2 (PAR2) decreased the ...
1) EGFR signal transduction pathway EGFR信号途径2) signaling pathway 信号途径 1. It is demonstrated that phosphorylation and dephosphorylation of NRs play a critical role in a variety of signaling pathways. 研究表明,核受体的磷酸化与去磷酸化在多条信号途径中起着重要作用。 更多例句>> ...