The signal transduction pathway underlying this effect in fibroblasts is mediated through Rac, a member of the Ras-like family of GTPases [1] ; [2] . As ruffles are rich in components of the cytoskeleton 鈥 particularly in actin and ezrin 鈥 it has been suggested that ruffles arise ...
To explore the signal transduction pathway of EGF in endometrial cells, we used cultured human endometrial cells to examine whether EGF induces tyrosine-phosphorylation. EGF phosphorylated the 175 kDa protein on tyrosine residues within 10 seconds of stimulation. EGF induced tyrosine phosphorylation at ...
Epidermal Growth Factor (EGF) Signaling Transduction The binding between EGFR and ligand triggers series of downstream intracellular signaling transduction. The RAS-RAF-MEK-MAPK pathway, which controls gene transcription, cell-cycle progression from the G1 phase to the S phase, and cell proliferation...
MAPK10, MAPK3, MAPK8, MAPK9, PPP2CA, PRKCA, SHC1. PI3K / Phosphoinositide 3-kinase Cascade: PIK3CA, PIK3R1, PIK3R2, PTEN. Small GTPase Mediated Signal Transduction: GRB2, HRAS, NRAS, NUP62, RAP1A, RASA1, RHOA. Other Intracellular Signaling Molecules: ARAF, BRAF, CBL, CSNK2A1, C...
EGF is a growth factor that activates a signal transduction pathway promoting proliferation, migration and differentiation; nevertheless, some inves- tigators showed that, after EGF binding to its receptor, they are both internalized, sourcing the formation of endosomes and ultimately degradation.19,20...
The detection of mutated ras oncogene in the transformed cell lines, taken together with the EGF receptor findings, suggests that more than one alteration in the signal transduction pathway may be necessary for transformation in alveologenic adenoma and carcinoma cell systems. A further phenotypic ...
Our study, for the first time, reveals a critical role of nonproteolytic ubiquityla- tion of an RNA-binding protein in a signal transduction pathway. Given that RNA-binding proteins have important roles in post-transcriptional gene expression regulation, the function of Ub modification of RNA-...
transduced by Ad-x-CTCF was observed in corneas of wild-type mice, and transduction of CTCF had a lesser effect on the wound healing in corneas from p50 knockout mice, indicating that the effect of CTCF on corneal epithelial wound healing is associated with the NFκB-p50 subtype pathway....
These proteins trigger several signal transduction cascades, such as extracellular signal-regulated kinase (ERK-MAPK), PI3K-AKT, SRC, PLC-γ1-PKC, JNK and JAK-STAT pathways that promote the activation of many cellular pathways, including cell proliferation, differentiation, migration, angiogenesis and...
MAPK cascade activation of MAPKK activity activation of MAPK activity angiogenesis platelet degranulation DNA replication signal transduction activation of transmembrane receptor protein tyrosine kinase activity epidermal growth factor receptor signaling pathway STAT protein import into nucleus positive regulation of...