In summary, our findings suggest that EGFL7 is a key factor for regulation of EGFR signaling pathway and plays an important role in migration and invasion of invasive GHPA.doi:10.1007/s11427-018-9320-4cnkiScience China Life Sciences
amphiregulin, TGF-α, betacellulin,etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation,survival and differentiation. Binding of a ligand induces EGFR protein homo
7. Chong M, Barritt G, Crouch M. 2004. Insulin potentiates EGFR activation and signaling in fibroblasts. Biochemical and Biophysical Research Communications. 322(2):535-541.8. Krug AW, Schuster C, Gassner B, Freudinger R, Mildenberger S, Troppmair J, Gekle M. 2002. Human Epidermal Growt...
The evolutionary conservation of all the components of the EGFR signaling pathway in Nematode, Fruit fly, Mouse, and Man underscores the biological significance of this signaling pathway. Furthermore, aberrant regulation of the activity or action of EGFR and other members of the RTK family have ...
EGF 刺激下沉默 PKM2 基因后能促进细胞的 HYPERLINK \l _bookmark4 迁移和侵袭 18 HYPERLINK \l _bookmark5 3.1.1 结果18 HYPERLINK \l _bookmark6 3.1.2 结果分析20 HYPERLINK \l _bookmark7 si-PKM2 后通过 E-Cadherin 的表达下降,进而调控 EGF/EGFR 下游信号通路 HYPERLINK \l _bookmark7 PLC-γ1...
EGF / PDGF Signaling Pathway PCR ArrayMouseGene ExpressionPAMM-040Z EGF / PDGF Signaling Pathway PCR ArrayRatGene ExpressionPARN-040Z Epidermal Growth Factor Receptor Signaling Pathway: BCAR1, CBL, EGF, EGFR, EPS8, GAB1, GRB2, HBEGF, NCK2, NUP62, RPS6KA5, SHC1. Platelet-Derived Growth...
Although the EGFR signaling pathway is important in skin development and homeostasis8,9, some studies on this signaling pathway have produced mixed results in AD. In one study, EGFR activation by EGF was found to protect against AD by decreasing IL-17A and IL-6 expression in an AD model15....
We report a mechanism by which the adapter protein Gene 33 (also called RALT and MIG6) regulates epidermal growth factor receptor (EGFR) signaling. We find... D Xu,A Makkinje,JM Kyriakis - 《Journal of Biological Chemistry》 被引量: 189发表: 2005年 Gene 33 Is an Endogenous Inhibitor of...
Here, we demonstrated that trophoblasts-derived EGF bound to EGFR, which was higher expressed on the surface of CXCR4 SP sp dNK cells than that of CXCR4 SP - sp dNK cells, and activated the ERK1/2 signaling pathway to promote the expression of MMP9 in CXCR4 ...
The EGF receptors (EGFRs) signaling pathway is essential for tumorigenesis and progression of cancer. Emerging evidence suggests that miRNAs are essential regulators of EGF signaling, influencing various pathway components and tumor behavior. This article discusses the underlying mechanisms and clinical impl...