7. Chong M, Barritt G, Crouch M. 2004. Insulin potentiates EGFR activation and signaling in fibroblasts. Biochemical and Biophysical Research Communications. 322(2):535-541.8. Krug AW, Schuster C, Gassner B, Freudinger R, Mildenberger S, Troppmair J, Gekle M. 2002. Human Epidermal Growt...
Moreover, Sorcin controls EGFR proteostasis and signaling and increases its phosphorylation, leading to increased EGF-dependent migration and invasion. Of note, silencing of Sorcin cooperates with EGFR inhibitors in the regulation of migration, highlighting calcium signaling pathway as an exploitable target...
EGF / PDGF Signaling Pathway PCR ArrayMouseGene ExpressionPAMM-040Z EGF / PDGF Signaling Pathway PCR ArrayRatGene ExpressionPARN-040Z Epidermal Growth Factor Receptor Signaling Pathway: BCAR1, CBL, EGF, EGFR, EPS8, GAB1, GRB2, HBEGF, NCK2, NUP62, RPS6KA5, SHC1. Platelet-Derived Growth...
The evolutionary conservation of all the components of the EGFR signaling pathway in Nematode, Fruit fly, Mouse, and Man underscores the biological significance of this signaling pathway. Furthermore, aberrant regulation of the activity or action of EGFR and other members of the RTK family have ...
EGFR对Janus激酶(JAK)的磷酸化导致转录蛋白信号换能器和激活器(STATs)的激活,最终导致细胞的生长和分化。EGF信号的另一个关键方面涉及磷脂酶c - γ1 (PLCγ1),它将PIP2裂解为IP3和DAG。IP3的产生导致内质网钙的释放,而DAG促进蛋白激酶C (PKC)的激活。PKC反过来磷酸化并激活转录因子Elk-1,导致细胞增殖。已知...
EGF 通过与表皮生长因子受体 EGFR 结合发挥其活性。EGFR 属于受体酪氨酸激酶家族,当没有受体结合时处于失活状态。EGF 与受体结合后引起受体二聚化,激活受体的酪氨酸残基自磷酸化,被激活的受体招募不同的信号序列蛋白,如刺激 Ras 蛋白,活化的 Ras 蛋白引起蛋白激酶的磷酸化级联反应,或激活磷脂酰肌醇激酶-3 (PI3K)...
promotes the activation of EGFR signaling pathway, including the activation of HIF1α that binds IL9 promoter, resulting in IL-9 production and enhancement of Th9 cell differentiation.DThe binding of HB-EGF to EGFR causes STAT5 expression, that leads to IL-2 production involved in the survival...
EGF 刺激下沉默 PKM2 基因后能促进细胞的 HYPERLINK \l _bookmark4 迁移和侵袭 18 HYPERLINK \l _bookmark5 3.1.1 结果18 HYPERLINK \l _bookmark6 3.1.2 结果分析20 HYPERLINK \l _bookmark7 si-PKM2 后通过 E-Cadherin 的表达下降,进而调控 EGF/EGFR 下游信号通路 HYPERLINK \l _bookmark7 PLC-γ1...
EGF 通过与表皮生长因子受体 EGFR 结合发挥其活性。EGFR 属于受体酪氨酸激酶家族,当没有受体结合时处于失活状态。EGF 与受体结合后引起受体二聚化,激活受体的酪氨酸残基自磷酸化,被激活的受体招募不同的信号序列蛋白,如刺激 Ras 蛋白,活化的 Ras 蛋白引起蛋白激酶的磷酸化级联反应,或激活磷脂酰肌醇激酶-3 (PI3K)...
crucial role in growth factor and hormone receptor down-regulation, this signaling pathway has also been proposed to regulate endosomal membrane transport and multivesicular endosome biogenesis. Here, we have followed the fate of the down-regulated EGF receptor (EGFR) and bulk transport (fluid......