2024年4月，《The Lancet Gastroenterology & Hepatology》杂志发表了题为《Targeting the EGFR signalling pathway in metastatic colorectal cancer》一文，深入探讨了表皮生长因子受体（EGFR）信号通路在结直肠癌发展中的关键作用，以及如何通过精准医疗策略克服治疗中的困境。研究方法 该研究是一项系统综述，旨在综合分析EGF...
改善患者筛选、提高针对EGFR通路的现有治疗疗效,以及开发新的联合策略,是目前克服转移性结直肠癌抗药性的重要挑战。 2024年4月,《The Lancet Gastroenterology & Hepatology》杂志发表了题为《Targeting the EGFR signalling pathway in metastatic colore...
EGFR signallingCancer TherapyDacomitinibCELL LUNG-CANCERGROWTH-FACTOR RECEPTORNASOPHARYNGEAL CARCINOMA-CELLSIntroduction Epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed, and mutated in multiple cancers. In normal cell physiology, EGFR signaling controls cellular differentiation, ...
改善患者筛选、提高针对EGFR通路的现有治疗疗效,以及开发新的联合策略,是目前克服转移性结直肠癌抗药性的重要挑战。 2024年4月,《The Lancet Gastroenterology & Hepatology》杂志发表了题为《Targeting the EGFR signalling pathway in metastatic colorectal cancer》一文,深入探讨了表皮生长因子受体(EGFR)信号通路在结直肠...
Targeting the EGFR signaling pathway in cancer therapy Introduction: Cancer is a devastating disease; however, several therapeutic advances have recently been made, wherein EGFR and its family members have emer... Parthasarathy Seshacharyulu,Moorthy P Ponnusamy,Dhanya Haridas,... 被引量: 0发表: ...
EGFR signalling from the endosome: is there a link to cancer development? Endocytosis of EGFR is initiated upon ligand binding but, as described above, multiple molecular factors are involved in the process. Endosome-associated EGFR is able to generate most, if not all, of its signal transductio...
Cell signalling Non-small-cell lung cancer Preclinical research Prognostic markers This article is cited by Prognostic impact of nectin-like molecule-5 (CD155) expression in non-small cell lung cancer Popa-Navarro Xitlally Avilés-Salas Alejandro ...
Mutations in components of the pathway are commonly involved in human cancer.(1) Ligand processing: Different mechanisms are employed in vertebrates and invertebrates for processing the ligand in the signal-producing cell to generate the secret-ed, active form. In Drosophila, the ligand precursor ...
Analysis of GPCR-induced EGFR activation in more than 60 human carcinoma cell lines derived from different tissues has demonstrated the broad relevance of this signalling mechanism in cancer. Moreover, EGFR signal transactivation was linked to diverse biological processes in human cancer cells, such ...
signalling pathway. Finally, the positive correlation of RHBDD1 expression with the EGFR/Raf/MEK/ERK signalling pathway is further corroborated in a murine model of colitis-associated colorectal cancer. These findings provide evidence of a growth-promoting role for RHBDD1 in colorectal cancer and ...