The physiological function of the Epidermal Growth Factor Receptor (EGFR) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of tumorigenesis. Inappropriate activation of the EGFR in cancer...
Emerging functions of the EGFR in cancerdoi:10.1002/1878-0261.12155Sara SigismundDaniele AvanzatoLetizia LanzettiSigismund S, Avanzato D, Lanzetti L. Emerging functions of the EGFR in cancer. Mol Oncol. 2017; 10: 1878-0261.
The interaction between programmed cell death ligand 1 (PD-L1), which is expressed on the surface of tumor cells, and programmed cell death 1 (PD-1), which is expressed on T cells, impedes the effective activation of tumor antigen-specific T cells, resulting in the evasion of tumor cells ...
Structure and functions of EGFR.AEGFR exon boundaries and associated extracellular, transmembrane, and intracellular protein domains. EGFR is involved in multiple signaling pathways and regulates numerous cell functions.BThe tyrosine kinase domain of EGFR and the activation or inactivation of the catalytic...
The EGFR has been associated with the pathogenesis and progression of breast cancer. Treatment based on an EGFR target is emerging as a promising option, especially in combination with conventional therapies. Unfortunately, there are no validated predictor biomarkers, and combinatorial treatments are ...
Oncogenic alteration of the endocytic machinery is a hallmark of cancer. As reviewed here, these alterations can lead to changes in morphology, polarity, motility, adhesion and growth factor-activated signalling pathways. Once engaged by soluble or matri
Herein, we review the current knowledge regarding circRNA biogenesis, regulation and functions in cancer as well as their clinical potential as biomarkers, therapeutic agents and drug targets. Key points Human cells produce many more unique circular RNAs (circRNAs) than we have protein-coding genes;...
The phosphorylation of protein residue results into the functions of protein. Tyrosine kinase function in many signal transduction cascades wherein extracellular signal is transmitted through the cell membrane receptors (EGFr/FGFr/PDGFr/C-src) to the nucleus where gene encoding this receptor protein ...
and regulating the activity of proteins or altering their cellular localization [5]. LncRNAs can also participate in multiple signal pathways of cancer (such as p53, AKT, or Notch), epigenetic control, DNA damage, multiple biological functions (e.g., tumor proliferation, metabolism, and apoptosis...
In this Review, we describe recent cancer genomic studies that have assembled emerging views of the landscapes of somatic mutations through deep-sequencing analyses of the coding exomes and whole genomes in various cancer types. We discuss the comparative genomics of different cancers, including ...