15. Ueno H, Sasaki K, Miyagawa K, Honda H, Mitani K, Yazaki Y, Hirai H. 1997. Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling. Journal of Biological Chemistry. 272(13):8739-874...
EGF / PDGF Signaling Pathway PCR ArrayRatGene ExpressionPARN-040Z Epidermal Growth Factor Receptor Signaling Pathway: BCAR1, CBL, EGF, EGFR, EPS8, GAB1, GRB2, HBEGF, NCK2, NUP62, RPS6KA5, SHC1. Platelet-Derived Growth Factor Receptor Signaling Pathway: BCAR1, PDGFA, PDGFB, PDGFRA, ...
EGFreceptoractivatesrasandtheMAPkinasepathway,ultimatelycausingphosphorylationoftranscription factorssuchasc-FostocreateAP-1andELK-1thatcontributetoproliferation.ActivationofSTAT-1andSTAT-3 transcriptionfactorsbyJAKkinasesinresponsetoEGFcontributestoproliferativesignaling. ...
Receptor tyrosine kinase (RTK) signaling is required for cell fate specification, cell proliferation, cell survival and cell morphological changes. EGF receptor (EGFR) activates the canonical Ras/Raf/MAPK pathway during retinal fate specification. EGFR plays roles in cell survival, proliferation, and ...
15. Ueno H, Sasaki K, Miyagawa K, Honda H, Mitani K, Yazaki Y, Hirai H. 1997. Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling. Journal of Biological Chemistry. 272(13):8739-874...
EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation of aldose reductase expression under oxidative stress. Free Radic Biol Med. 2001; 31 :205–216.Nishinaka, T.; Yabe-Nishimura, C. EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation ...
15. Ueno H, Sasaki K, Miyagawa K, Honda H, Mitani K, Yazaki Y, Hirai H. 1997. Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling. Journal of Biological Chemistry. 272(13):8739-874...
美国田纳西州纳什维尔范德比尔特大学肾病中心的Raymond C. Harris团队,于2019年7月在知名学术期刊《J Am Soc Nephrol》上发表了题为“The Role of the EGF Receptor in Sex Differences in Kidney Injury”的文章[2],为我们揭示了肾脏损伤中存在性别差异这一有趣现象。研究结果表明,EGF在性别间表达的差异可能是慢性...
Binding of EGF to the extracellular domain of EGFR leads to receptor dimerization, activation of the intrinsic PTK (Protein Tyrosine Kinase) activity, tyrosine autophosphorylation, and recruitment of various signaling proteins to these autophosphorylation sites located primarily in the C-terminal tail of ...
The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cells, bone cells, blood and immune cells, heart cells, glia and stem neural cells. It belongs to the ErbB family, which includes three