Tyrosine kinase receptors play a significant role in multiple cellular processes and contribute to cancer development. NGF and EGF were the first tyrosine kinase receptors discovered in the year 1960s. There are about 20 classes of these receptors present to date. ...
G protein-coupled receptorsintracellular signallingEGF receptor transactivationMAPKProtein substitutes are an essential component in the management of phenylketonuria. A series of studies at Birmingham Children's Hospital have investigated their optimal dosage, timing and practical administration as well as the...
Studies have found that people who develop skin tags have higherinsulingrowth factor (IGF-1) levels and more insulin growth factor receptors. These receptors are found in the skin and could be responsible for skin tag formation on the eyelids. Epidermal growth factor (EGF) and its receptors reg...
Epidermal growth factor receptors (EGFRs) were measured in 221 primary breast cancers by ligand binding with 125I-labelled EGF, and high-affinity sites wer... AL Harris,S Nicholson,J Richard,... - 《Journal of Steroid Biochemistry》 被引量: 467发表: 1989年 Immunohistochemical study of steroid...
• PI3K/AKT, MAPK, JAK-STAT, and RAP1 pathway receptors are enriched on the CHO cell surface and downstream pathways present on mRNA level. • Detected pathways indicate strong CHO survival and growth phenotypes. • Potential self-induction of surface receptors and respective ligands. Graphica...
The latter domain can combine with other cell surface receptors and ECM molecules such as integrins and fibronectin [144]. TNC+ CAFs are mainly derived from MSCs [34]. In pancreatic cancer, high expression of TNC in CAFs activates downstream signaling through the Annexin II receptor, ...
How- ever, recent studies indicate that EGF may have a function in aiding RGC survival; it has been found that Nell2, an EGF-re- lated gene, supports RGC survival after optic nerve injury[174]. Vascular endothelial growth factor (VEGF) exists as several isoforms, VEGF-A, -B, -C, and...
What is the EGF receptor in cell signaling? What are hydrophilic signaling molecules? What is SRC in cell signaling? What does Ras do during tyrosine kinase cell signaling? What is the JAK-STAT pathway for cell signaling? What signaling pathways control cell migration? What is key for B-cell...
Zhang Z, Liu ZB, Ren WM, Ye XG, Zhang YY (2012) The miR-200 family regulates the epithelial-mesenchymal transition induced by EGF/EGFR in anaplastic thyroid cancer cells. Int J Mol Med 30:856-62. doi: https://doi.org/10.3892/ijmm.2012.1059. Article CAS PubMed Google Scholar Vosgha...
Studies have found that UC-MSCs genes related to cell proliferation (EGF), PI3K-NFkB signaling pathway (TEK), and neurogenesis (RTN1,NPPB, andNRP2) were upregulated (increase in the number of receptors) in UC-MSCs compared to in BM-MSCs. (15) ...