NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancerHER2+ breast cancer (BC) is characterized by rapid growth, early recurrence, early metastasis, and chemoresistance. Trastuzumab is the most effective treatment for HER2+ BC and effectively ...
进一步采用qPCR技术检测STAT3靶基因CyclinD1和cmyc的表达,10-姜酚能剂量依赖性的降低CyclinD1和cmyc的表达,与对照组比较差异有统计学意义(P < 0.01,图4C、D)。 图4 10-姜酚抑制STAT3信号通路激活 Figure 4 10-gingerol inhibits activation of STAT3 signaling pathway (*P < 0.05 vs control). A: Western ...
In conclusion, we identified the AhR-Src-STAT3-IL-10 signaling pathway as a critical pathway in the immune regulation of inflammatory macrophages, It suggests that AhR may be a potential therapeutic target in immune response. 展开 关键词: aryl hydrocarbon receptor, IL-10, macrophages, inflammation...
[关键词] Src 酪氨酸激酶; 信号转导子和转录激活子 3; 高糖; 血管平滑肌; 细胞增殖; 细胞迁移 [中图分类号] R587.1;R363.2 [文献标志码] Adoi:10.3969/j.issn.1000⁃4718.2017.07.014Highglucoseinducesvascularsmoothmusclecellproliferationandmigra⁃tionthroughactivationofSrc/Stat3signalingpathwayWANGJun,...
GSH, a ROS scavenger, abrogated the inhibitory effect of PQ on the JAK2/Src-STAT3 pathway in human HCC cells. These results suggested that PQ inhibited the STAT3 signaling pathway through the generation of ROS in human HCC cells. 展开
选择10-姜酚低,中,高浓度(1,3,10 μmol/L)处理肝癌细胞HepG2 24 h,同时设立正常对照组.MTT检测各组细胞活力;EdU染色检测各组细胞增殖并计算阳性细胞数;Western blot检测Src(p-Src)及STAT3(p-STAT3)的表达水平;qPCR技术检测STAT...
摘㊀要:类固醇受体辅激活因子(ＳｔｅｒｏｉｄｒｅｃｅｐｔｏｒｃｏａｃｔｉｖａｔｏｒꎬＳｒｃ)是一种由Ｓｒｃ原癌基因编码的非受体型酪氨酸激酶ꎬ属于Ｓｒｃ家族蛋白激酶(Ｓｒｃ￣ｆａｍｉｌｙｋｉｎａｓｅｓꎬＳＦＫｓ)的核心成员.Ｓｒｃ广泛存在于人体细胞中ꎬ可调节细胞分裂㊁运动㊁黏附㊁血管生成和存活...
Activation of protein tyrosine kinases is prevalent in human cancers and previous studies have demonstrated that Stat3 signaling is a point of convergence for many of these tyrosine kinases. Moreover, a critical role for constitutive activation of Stat3 in tumor cell proliferation and survival has bee...
【关键词】上皮性卵巢癌；c-Src;P-STAT3;实时荧光定量PCR;免疫组织化学 中图分类号：R737.31 文献标志码：A The Relationship between c-Src and p-STAT3 Signaling Pathway in the Occur rence and Development of Epithelial Ovarian Cancer YA N G X ia o ro n g’TA N N a，H U AN G J ia...
Furthermore, the protein phosphatase activity of PTEN plays a major role in the negative regulation of the Src/Stat3 pathway and represses podosome formation. Our data suggest that cellular invasiveness is dependent on the balance between two opposing forces: the proinvasive oncogenes Src-Stat3 and...