Her family was positive for colon and endometrial cancer, and the tumor showed loss of MSH-6 expression; however, mutation analysis was negative for Lynch syndrome. Both women did not use tamoxifen in the past. After risk-reducing salpingo-oophorectomy, 4 women (all BRCA1 carriers) underwent...
The estimated BC hazard ratios (HRs) for the 74 known BC alleles inBRCA1carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC inBRCA1carriers were more consistent with the ER-positive associations in t...
GCAT TACG genesG C A T Review Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules Judit Jimenez-Sainz 1,* and Ryan B. Jensen 1,2,* 1 Department of Therapeutic Radiology, Yale ...
, the aim of the present study was to assess the secretory function of salivary glands, selected salivary biomarkers of redox balance, and oxidative damage to proteins and lipids in subjects with breast cancer as compared to patients without breast cancer, positive or not positive for BRCA1. ...