Preimplantation genetic diagnosis for BRCA1 exon 13 duplication mutation using linked polymorphic markers resulting in a live birth. Prenat Diagn 2008;28:292- 298.Jasper MJ,Liebelt J,Hussey ND.Preimplantation genetic diagnosis for BRCA1 exon 13 duplication mutation using linked polymorphic markers ...
This study aimed to determine whether constitutional methylation of the BRCA1 promoter region was a predisposition factor for ovarian cancer. We had previously shown that in a case control study of early-onset breast cancer patients, the... A Dobrovic,T Mikeska,K Alsop,... - 《Cancer Researc...
Characteristics of BRCA1 mutations in a population-based case series of breast and ovarian cancer Breast and ovarian cancers account for approximately 210000 newly diagnosed cases per year. More than half a million American women are estimated to be car... H Anton-Culver,PF Cohen,ME Gildea,.....
In this work, we provide a brief review of representative works that focus on integrating pathomics and genomics for cancer diagnosis, treatment, and prognosis, including the correlation of pathomics and genomics, fusion of pathomics and genomics. We also present challenges, potential opportunities, ...
Hormone-receptor positive (HR+) breast cancer (BC) (including the luminal A and the luminal B subtypes) is the most common type of tumor in women diagnosed
Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab therapy with multi-course treatment, and 90...
With ITS1 PCR, irrespective of the addition of Q-solution, we observed a higher number of positives for all the trypanosome species compared to ITS1 TD PCR and nested ITS PCR. Adding Q-solution in the PCR mixture of ITS1 TD PCR profoundly decreases the number of positive reactions from ...
a positive correlation (PCC = 0.8198) occurred between the deconvolution metric RMSE and the detection metric 1 - AUC, as shown in Fig.3b, suggesting that the AUC can also be used to quantify the accuracy of predicted tumor fractions, especially for diagnosis using patient cfDNA since thei...
biomarkers are reportedly unreliable as they generate a significant amount of false-positive and/or false-negative results. Plasma alpha fetoprotein (AFP), one of the most frequently used biomarkers for diagnosis of hepatocellular carcinoma (HCC)1, has been described by many ...
For each type, the tree with the minimum value of the Gini index (this is the default in rpart) was selected subject to the constraint of a minimum node size (bucket size) of 10. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy and ...