Additional multigene panels led to the detection of 23 additional BRCA-positive patients with germline co-mutations and/or variants of uncertain significance in genes functionally involved in DNA repair mechanisms. Hispanic or Latino and Asian individuals comprised 45% of patients with concomitant ...
Her family was positive for colon and endometrial cancer, and the tumor showed loss of MSH-6 expression; however, mutation analysis was negative for Lynch syndrome. Both women did not use tamoxifen in the past. After risk-reducing salpingo-oophorectomy, 4 women (all BRCA1 carriers) underwent...
carried out association analyses by subtype for the following breast cancer characteristics: ER-positive and ER-negative, PR-positive and PR-negative, HER2-positive and HER2-negative, TN breast cancer (that is, negative for ER, PR and HER2) and non-TN (that is, tumor positive for at least ...
Controversy remains as some studies demonstrated no correlation, and others, a positive correlation between BRCA2 mutations in the BRC domain and ovarian cancer patient survival [73,74]. Discrepancies arise in part due to the selection of the BRCA2 mutations (missense, indels, etc.), the number...
Therefore, the aim of the present study was to assess the secretory function of salivary glands, selected salivary biomarkers of redox balance, and oxidative damage to proteins and lipids in subjects with breast cancer as compared to patients without breast cancer, positive or not positive for ...