Additional multigene panels led to the detection of 23 additional BRCA-positive patients with germline co-mutations and/or variants of uncertain significance in genes functionally involved in DNA repair mechanisms. Hispanic or Latino and Asian individuals comprised 45% of patients with concomitant ...
Her family was positive for colon and endometrial cancer, and the tumor showed loss of MSH-6 expression; however, mutation analysis was negative for Lynch syndrome. Both women did not use tamoxifen in the past. After risk-reducing salpingo-oophorectomy, 4 women (all BRCA1 carriers) underwent...
carried out association analyses by subtype for the following breast cancer characteristics: ER-positive and ER-negative, PR-positive and PR-negative, HER2-positive and HER2-negative, TN breast cancer (that is, negative for ER, PR and HER2) and non-TN (that is, tumor positive for at least ...