Molecular signatures are the most intuitive measurements of response to therapeutic interventions, while survival analysis for cancer prognosis prediction is a standard approach for biomarker discovery, stratification of patients into different treatment groups, and therapeutic response prediction [43]. Many s...
the effectiveness of PARPi in LMS, we compared LMS cell line responsiveness to primary UPS cell lines (n = 5, see Supplementary Data9) and controls: (1) a CRISPRTP53deletion (RPEΔp53, HR-intact) cell, (2) aTP53andBRCA1deletion (RPEΔp53ΔBRCA1, HR-deficient34), and (3) Hs ...
Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab therapy with multi-course treatment, and 90...
Although its popularity influenced by false-positive results for inflammation and infection, PET-CT can be applied to stage pleural disease [30]. Nonetheless, one study showed that PET-CT can identify benign and MPE with a sensitivity of 83.3% and specificity of 92.2% and developed and ...
biomarkers are reportedly unreliable as they generate a significant amount of false-positive and/or false-negative results. Plasma alpha fetoprotein (AFP), one of the most frequently used biomarkers for diagnosis of hepatocellular carcinoma (HCC)1, has been described by many ...
With ITS1 PCR, irrespective of the addition of Q-solution, we observed a higher number of positives for all the trypanosome species compared to ITS1 TD PCR and nested ITS PCR. Adding Q-solution in the PCR mixture of ITS1 TD PCR profoundly decreases the number of positive reactions from ...
Explain how the genetic code is used to make proteins. Discuss the entry, the life cycle, and the genetic components of the HIV virus. Give a biological example of negative feedback and describe the specific components involve...
Hormone-receptor positive (HR+) breast cancer (BC) (including the luminal A and the luminal B subtypes) is the most common type of tumor in women diagnosed
The use of CA125 in combination with IL-6, lowered false positive rates and achieved higher predictive values compared to CA125 alone. A similar pattern of improvement was also observed for RMI, HE4 or ROMA in combination with IL-6. However, IL-6 alone was not superior to the predictive ...
85% of BrdU-labeled cells were positive to DCX. Data are number of BrdU+ or DCX+ cells in mouse hippocampus (n=5), (F2,53=35.27; ***P<0.001 versus saline). C, Quantitation of BrdU positive cells of hippocampus treated with saline, fluoxetine or spadin (10−5 M) for 15 days. (...