Her family was positive for colon and endometrial cancer, and the tumor showed loss of MSH-6 expression; however, mutation analysis was negative for Lynch syndrome. Both women did not use tamoxifen in the past. After risk-reducing salpingo-oophorectomy, 4 women (all BRCA1 carriers) underwent...
carried out association analyses by subtype for the following breast cancer characteristics: ER-positive and ER-negative, PR-positive and PR-negative, HER2-positive and HER2-negative, TN breast cancer (that is, negative for ER, PR and HER2) and non-TN (that is, tumor positive for at least ...
Controversy remains as some studies demonstrated no correlation, and others, a positive correlation between BRCA2 mutations in the BRC domain and ovarian cancer patient survival [73,74]. Discrepancies arise in part due to the selection of the BRCA2 mutations (missense, indels, etc.), the number...