Her family was positive for colon and endometrial cancer, and the tumor showed loss of MSH-6 expression; however, mutation analysis was negative for Lynch syndrome. Both women did not use tamoxifen in the past. After risk-reducing salpingo-oophorectomy, 4 women (all BRCA1 carriers) underwent...
Recently, 45 additional SNPs have been found to be associated with breast cancer risk in the general population [8]-[10],[16]. Eighteen of these SNPs showed evidence of association with ER-positive breast cancer, but not with ER-negative breast cancer, and four loci (1q32.1 LGR6, 2p24.1...