oBRCA1/2相关遗传性乳腺和卵巢癌综合征(BRCA1/2-associated hereditary breast and ovarian cancer syndrome) o林奇综合征(Lynch syndrome) oCowden综合征(Cowden syndrome) oLi-Fraumeni综合征(Li-Fraumeni syndrome) oPeutz-Jeghers综合征(Peutz-Jeghers syndrome) o...
Therefore, we hypothesized that N1DARP destabilizes N1ICD by preventing its interaction with positive regulators, such as deubiquitinases (DUBs). The deubiquitinase BAP1 stabilizes N1ICD through the BRCA1–BARD1 complex45. However, we found that N1DARP was not involved in the BAP1-mediated ...