Shared and oppositely regulated transcriptomic signatures in Huntingtons disease and brain ischemia confirm known and unveil novel potential neuroprotective genesHuntington's disease (HD)NeurodegenerationSmall vessel ischemic disease (SVID)Subcortical vascular dementia (sVaD)...
We have tested whether small intraischemic variations in brain temperature influence the outcome of transient ischemia. To measure brain temperature, a thermocouple probe was placed stereotaxically into the left dorsolateral striatum of rats prior to 20 min of four-vessel occlusion. Rectal temperature ...
The post-treatment effects of the selective cyclooxygenase (COX)-2 inhibitor, valdecoxib, were investigated in a rat model of temporary focal ischemia. Val... E Candelario-Jalil,A González-Falcón,M García-Cabrera,... - 《Journal of Neurochemistry》 被引量: 248发表: 2007年 Blood-brain ba...
This can partly be explained by a lack of or a faint effect of antihypertensive therapy on the increased blood–brain barrier (BBB) permeability14, which, along with ischemia, is another significant mechanism of brain damage in hypertension15,16,17. BBB damage in patients with hypertension is ...
M. Cerebrovascular hemodynamics and ischemic tolerance: lipopolysaccharide-induced resistance to focal cerebral ischemia is not due to changes in severity of the initial ischemic insult, but is associated with preservation of microvascular perfusion. J. Cereb. Blood Flow Metab. 19, 616–623 (1999). ...
[164]. After intracarotid delivery of NSCs in an experimental model of brain hypoxia/ischemia in mice, the authors observed significantly higher numbers of CCR2+/+ transfected NSCs recruited to the ischemic brain areas as compared to CCR2−/− cells, proving the importance of CCR2 for...
Acerebral embolismis the occlusion of a cerebral vessel by some extraneous material (such as tumor cells, a clump of bacteria, air, or plaque fragments). This occlusion leads toischemia(a localized anemia) and, if prolonged, ultimately toinfarction(a localized vascular insufficiency resulting in ...
Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study.doi:10.1161/STROKEAHA.117.016467We aimed to determine the incidence of co-occurring cerebral ischemia, extent of cerebral small vessel disease, and vascular risk profile of ...
SGLT2 inhibitor dapagliflozin alleviates intramyocardial hemorrhage and adverse ventricular remodeling via suppressing hepcidin in myocardial ischemia-repe... Intramyocardial hemorrhage (IMH), a reperfusion therapy-associated complication, is the extravasation of red blood cells caused by severe microvascular in...
D. Thrombin mediates severe neurovascular injury during ischemia. Stroke 41, 2348–2352 (2010). Article CAS PubMed Google Scholar Schachtrup, C. et al. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor. Proc. Natl Acad. Sci. USA 104, 11814...