Chronic small vessel disease (SVD) has been shown to disrupt this network’s integrity and has been proposed as a predictor of poor outcome after stroke. We studied this hypothesis in patients with acute ischemic stroke of the striatocapsular region, an area of pronounced cortical and ...
Chronic small vessel disease (SVD) has been shown to disrupt this network's integrity and has been proposed as a predictor of poor outcome after stroke. We studied this hypothesis in patients with acute ischemic stroke of the striatocapsular region, an area of pronounced cortical and subcortical...
Cerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims ...
et al. Chronic remote ischemic conditioning is cerebroprotective and induces vascular remodeling in a VCID Model. Transl. Stroke Res. 9, 51–63 (2018). Article CAS PubMed Google Scholar Wardlaw, J. M. et al. Blood-brain barrier failure as a core mechanism in cerebral small vessel ...
Additionally, CKD-associated ischemic brain lesions may be the basis for cognitive decline. The Northern Manhattan Study and the Rotterdam Scan Study found that subjects with CKD, defined by reduced creatinine clearance or eGFR, had a greater burden of white matter hyperintensity volumes after ...
Recurrent phalangeal ulceration or persistent nonhealing occurs in 11% to 12 % of patients with ischemic finger ulceration, especially in patients with Buerger's or autoimmune disease. Although finger debridement and occasional partial phalangeal amputations are frequently necessary, complete digital or...
Two weeks of social isolation stress potentiated infarct size, brain edema, and MAC-1 expression (a microglia activation marker) suggesting that social isolation sensitized the neuroinflammatory response to an ischemic insult. However, social isolation blunted the central IL-6 response to MCAO. Several...
Orphan G protein-coupled receptor, GPR41, induces apoptosis via a p53/Bax pathway during ischemic hypoxia and reoxygenation. J Biol Chem. 2001;276(28):26453–60. Article CAS PubMed Google Scholar Inoue D, Tsujimoto G, Kimura I. Regulation of energy homeostasis by GPR41. Front Endocrinol. ...
a common sequela of small vessel brain disease46. Moreover, individuals with advanced brain age (i.e., older brain age than chronological age) present more severe language impairments after stroke than those with typical brain age47,48. Identifying the underlying neural processes associated with ...
et al. Global burden of small vessel disease-related brain changes on MRI predicts cognitive and functional decline. Stroke 51, 170–178 (2020). Article PubMed Google Scholar Chen, H. H. et al. The diagnostic accuracy of the Ascertain Dementia 8 questionnaire for detecting cognitive ...