Definition Cerebral small vessel ischemic disease (SVID) results from compromised functioning of the small penetrating cerebral arteries, causing reduced blood flow to deep white matter regions of the brain, leading to focal lacunar infarcts, diffuse ischemia (leukoaraiosis), vascular cognitive ...
We have tested whether small intraischemic variations in brain temperature influence the outcome of transient ischemia. To measure brain temperature, a thermocouple probe was placed stereotaxically into the left dorsolateral striatum of rats prior to 20 min of four-vessel occlusion. Rectal temperature ...
Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter...
CONCLUSIONS: Cerebral small vessel disease, with or without a history of cerebrovascular disease, is associated with increased risk of death and ischemic stroke in patients with atherosclerotic disease. 展开 关键词: Humans Cerebrovascular Disorders Brain Ischemia Magnetic Resonance Imaging Risk Factors ...
small vessel disease Acronyms Any of multiple small cerebral infarcts in the corona radiata, internal capsule, striatum, thalamus, basis pontis, and/or cerebellum, occasionally preceded by transient symptoms, due to occlusion or stenosis of small penetrating branches of the middle and posterior cerebral...
et al. Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70, 935–942 (2008). Article PubMed CAS Google Scholar Smith, E. E. et al. Early cerebral small vessel disease and brain volume, cognition, and gait. Ann. Neurol. 77, ...
Cerebral small vessel disease results in silent ischemic lesions (SIL) among which is leukoaraiosis. In this process, endothelial damage is probably involved. Endothelial progenitor cells (EPC), are involved in endothelial repair. By restoring the damaged endothelium, EPC could mitigate SIL and cere...
Cerebral small vessel disease (cSVD) is a collective term for different pathological processes that affect the small vessels of the brain, i.e. the small arteries and veins and the capillary beds. cSVD accounts for a quarter of ischemic strokes and is a main cause of vascular dementia (Debet...
Here, we show that bi-allelic NIT1 loss-of-function variants cause a genetic cerebral small vessel disease, resulting in a triad of movement disorders, massively dilated perivascular spaces on brain MRI, and fatal deep ICH. We describe the clinical phenotype, neuroimaging features, and brain vess...
renal small vessel disease may also be indicative of the presence of small vessel disease in the brain.30 On the other hand, levels of an endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine, are increased in patients with impaired kidney function.31 Such factors could accelera...