Functional Brain Activation in Mild Cognitive Impairment With Defined Small Vessel Disease Burdendoi:10.1002/alz.077890Marcolini, SofiaMondragon, JaimeRamakers, Inez H.G.B.Biessels, Geert JanClaassen, Jurgen A.H.R.Bron, Esther EPapma, Janne M....
Small Vessel Cerebrovascular Pathology Identified by Magnetic Resonance Imaging Is Prevalent in Alzheimer's Disease and Mild Cognitive Impairment: A Potent... magnetic resonance imagingneuropsychological testingsmall vessel pathologyThere is evidence that Alzheimer's disease (AD) has significant cerebrovascular...
Structural retinal changes in cerebral small vessel disease Article Open access 03 June 2022 Introduction Presently, the pathogenesis of cerebral small vessel disease (SVD) in humans is not completely understood, in part due to the difficulty in imaging in vivo the cerebral microvasculature. SVD is...
The pathophysiology of amnestic Mild Cognitive Impairment (aMCI) is largely unknown, although some papers found signs of immune activation. To assess the cytokine network in aMCI after excluding patients with major depression (MDD) and to examine the imm
Ischemic brain lesions associated with hypertension (HTN). HTN induces atherosclerosis of major extracranial and intracranial arteries, which could lead to major infarcts. HTN causes both microbleeds and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar ...
1,2 With life expectancies increasing dramatically in the last century, cognitive decline, mild cognitive impairment (MCI), and dementia have become major concerns.3,4 Aging is associated with gradual changes in the brain that impair its function. As a result, older people, even those without...
05. Conclusions The increased hs-CRP and Hcy levels of risk factors may occur in patients with small vessel disease of brain cognitive dysfunction,however high Hcy and hs-CRP levels may be involved in cognitive impairment in patients with small vessel brain. Therefore,early detection of plasma ...
Most patients with AD were diagnosed during dementia, but the irrever sible damage was found in the neurons of the brain. In the MCI stage, biomarkers can be used to identify potential clinical causes and to evaluate the severity of the disease. In the MCI period, timely and accurate ...
Twenty-Four Hours of Mild Hypothermia in Unsedated Newborn Pigs Starting after a Severe Global Hypoxic-Ischemic Insult Is Not Neuroprotective MARIANNE THORESEN, SAULIUS SATAS, ELSE MARIT LØBERG, ANDREW WHITELAW, DOMINIQUE ACOLET, CARL LINDGREN, JULIET PENRICE, NICOLA ROBERTSON, EGIL HAUG, AND ...
ultimately resulting in amyloid deposition. Furthermore, Zhao and Lukiwet al., also reported that microbiome-derived LPS was enriched in the perinuclear region of the AD brain14, whereas LPS was detected in the hippocampus of patients with AD9. Our findings are consistent with these studies becaus...