Background Vascular dysregulations and changes in functional brain network integrity play a fundamental role in the pathogenesis of dementia. While often identified in individuals with dementia, the role of smal
Structural retinal changes in cerebral small vessel disease Article Open access 03 June 2022 Introduction Presently, the pathogenesis of cerebral small vessel disease (SVD) in humans is not completely understood, in part due to the difficulty in imaging in vivo the cerebral microvasculature. SVD is...
The mechanism through which the gut microbiome affects human cognitive functions remains unknown, although animal studies strongly implicate the gut microbiome as a key regulator of the brain and behaviour15. The functional pathways through which the gut microbiome communicates with the brain, also known...
1,2 With life expectancies increasing dramatically in the last century, cognitive decline, mild cognitive impairment (MCI), and dementia have become major concerns.3,4 Aging is associated with gradual changes in the brain that impair its function. As a result, older people, even those without...
3). Laromestrocel ameliorated this decline in all treatment groups relative to placebo (Fig. 3). Representative volumetric MRI (vMRI) images depict changes in brain volume in group 1 versus group 4 at week 39 (increase, yellow; decrease, blue) (Fig. 3a). While the 25 M × 1 ...
管病合并高同型半胱氨酸血症患者认知功能的影响 the efficacy of folic acid combined with mecobalamine for the treatment of mild cognitive impairment in patients with cerebral small vessel disease and hyperhomocysteinemia 下载文档 收藏 打印 转格式 管...
Effect sizes were small but persisted after controlling for a 10% false discovery rate. LTRA use was not associated with changes in memory performance in AD, nor was it associated with changes in cognitive performance in people with normal cognition or MCI. In a post hoc analysis, LTRA use ...
Ischemic brain lesions associated with hypertension (HTN). HTN induces atherosclerosis of major extracranial and intracranial arteries, which could lead to major infarcts. HTN causes both microbleeds and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar ...
Dementia is a neurocognitive disorder characterized by a progressive memory loss and impairment in cognitive and functional abilities. Autophagy and mitophagy are two important cellular processes by which the damaged intracellular components are degraded by lysosomes. To investigate the contribution of autopha...
Twenty-Four Hours of Mild Hypothermia in Unsedated Newborn Pigs Starting after a Severe Global Hypoxic-Ischemic Insult Is Not Neuroprotective MARIANNE THORESEN, SAULIUS SATAS, ELSE MARIT LØBERG, ANDREW WHITELAW, DOMINIQUE ACOLET, CARL LINDGREN, JULIET PENRICE, NICOLA ROBERTSON, EGIL HAUG, AND ...