While SHP gene induction by increased bile acids is well established, whether SHP activity is also modulated remains unknown. Here, we report surprising findings that SHP is a rapidly degraded protein via the ubiquitin-proteasomal pathway and that bile acids or bile acid-induced intestinal fibroblast...
The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi-enzymatic bile-acid biosynthetic pathway. Bile acids play a crucial role in dietary lipid digestion and absorption, and also act as versatile signalling molecules through the activation of the...
Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs) are notable for the fact that they were hiding in plain sight. BAs were well known for their requirement in dietary lipid absorption and biliary cholesterol secr
Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid...
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. 来自 Wiley 喜欢 0 阅读量: 51 作者:Y Fang,IH Song,C Mitchell,S Gupta,E Studer,S Grant,PB Hylemon,P Dent ...
Bile acids perform vital functions in the human liver and are the essential component of bile. It is therefore not surprising that the biology of bile acids is extremely complex, regulated on different levels, and involves soluble and membrane receptors
Similarly, KEGG pathway analysis revealed an enrichment of pathways related to lipid metabolism and carbohydrate metabolism. Among them, 'AMPK signaling pathway' which is critical in balancing cellular energy, was significantly enriched after bile acids activation. In addition, pathways of 'Fatty acid ...
TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies in vivo, we ...
our study provided new insight into the relationship between chronic insomnia and bile acids. Bile acids are recognized as potent signaling molecules that impact glucose and lipid homeostasis through activation of Farnesoid-X receptor (FXR)42,43,44and Takeda-G-protein-receptor-5 (TGR5)45. As alter...
bile acids function as pleiotropic signaling molecules that mediate the crosstalk between the gut and liver57,58. The intricate interaction between bile acids and the gut flora (which involves mutual dependency and inhibition) is crucial for maintaining mammalian homeostasis. Bile acids that have not ...