Bile acids (BA) are the result of hepatic cholesterol oxidation. BA control their synthesis, transport, and detoxification and help intestinal lipid absorption. BA are also signaling molecules and activate nuclear receptors such as FXR, CAR, PXR, and VDR, together with the G protein-coupled ...
Bile acids (BAs) can regulate their own metabolism and transport as well as other key aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors. Disrupted BA transport and homeostasis results in the development of cholestatic disorders and contributes to a wide range ...
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-021-00566-7 (2022). Article PubMed Google Scholar Hamilton, J. P. et al. Human cecal bile acids: concentration and spectrum. Am. J. ...
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology Article 14 February 2022 The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer Article 10 February 2021 Bile acids and the gut microbiota: metabolic interactions and impact...
Bile acids and their nuclear receptor FXR: relevance for hepatobiliary and gastrointestinal disease Biochim Biophys Acta, 1801 (2010), pp. 683-692 View PDFView articleView in ScopusGoogle Scholar 68 AB Schote, JD Turner, J Schiltz, CP. Muller Nuclear receptors in human immune cells: expression...
Bile acid sequestrants(BASs) bind tobile acidsin the intestine and inhibit their absorption. Bile acids are derived from cholesterol and increasedbile excretionsignificantly lowers the cholesterol content of the body. It is an effective cholesterol-lowering agent without any serious side effect.22It ...
In the liver environment hepatocytes and biliary epithelial cells express TRAIL receptors which are up-regulated by increased levels of bile acids and during... N Pelli,A Floreani,F Torre,... - 《Clinical & Experimental Immunology》 被引量: 46发表: 2010年 Bile acids and their receptors: Poten...
In recent years, bile acids and their analogues have been extensively utilized as supramolecular receptors for various types of guest molecules and ions. Under certain defined conditions, the supramolecular association of bile acids and their derivatives leads to gel formation. Thus, modified bile ...
C.Bile acids and derivatives,their nuclear receptors FXR,PXR and ligands:role in health and disease and their therapeutic potential.Anticancer Agents Med ... Amazia Zimber, Christian Gespach - Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 被引...
Bile acids perform vital functions in the human liver and are the essential component of bile. It is therefore not surprising that the biology of bile acids is extremely complex, regulated on different levels, and involves soluble and membrane receptors